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The maturation of rat brain myelin

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Lipids

Abstract

Myelin fractions were prepared from brains of 9- to 90-day-old rats by continuous and discontinuous sucrose density gradient procedures. Total protein and lipid content of myelin showed little variation, but lipid composition changed significantly during maturation. Cholesterol, galactolipids, and ethanolamine glycerophosphatide plasmalogen increased whereas choline glycerophosphatide content decreased with increasing age. The changes in lipid composition were more marked in the myelin prepared by the discontinuous gradient technique. The significance of these lipid changes in relation to their organization in the myelin membrane is discussed.

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References

  1. Hulcher, F. H., Arch. Biochem. Biophys.100, 237–244 (1963).

    Article  PubMed  CAS  Google Scholar 

  2. Nussbaum, J. L., R. Bieth and P. Mandel, Nature198, 586–587 (1963).

    Article  PubMed  CAS  Google Scholar 

  3. Autilio, L. A., W. T. Norton and R. D. Terry, J. Neurochem.11, 17–27 (1964).

    Article  PubMed  CAS  Google Scholar 

  4. Eichberg, J., V. P. Whittaker and R. M. C. Dawson, Biochem. J.92, 91–100 (1964).

    PubMed  CAS  Google Scholar 

  5. O'Brien, J. S., and E. L. Sampson, J. Lipid Res.6, 537–544 (1965).

    PubMed  Google Scholar 

  6. Norton, W. T., and L. A. Autilio, Ann. N. Y. Acad. Sci.122 Art. 1, 77–88 (1965).

    Article  PubMed  CAS  Google Scholar 

  7. Cuzner, M. L., A. N. Davison and A. N. Gregson, J. Neurochem.12, 469–481 (1965).

    Article  PubMed  CAS  Google Scholar 

  8. Evans, M. J., and J. B. Finean, Ibid.12, 729–734 (1965).

    Article  PubMed  CAS  Google Scholar 

  9. Norton, W. T., and L. A. Autilio, Ibid.13, 213–222 (1966).

    Article  PubMed  CAS  Google Scholar 

  10. Gerstl, B., L. F. Eng, R. B. Hayman, M. G., Tavaststjerna and P. R. Bond, Ibid.14, 661–670 (1967).

    Article  PubMed  CAS  Google Scholar 

  11. O'Bien, J., Sicence147, 1099–1107 (1965).

    Google Scholar 

  12. Cuzner, M. L., and A. N. Davison, “Variation in Composition of the Nervous System,” G. B. Ansell, editor, Pergamon Press, New York, 1966, p 22.

    Google Scholar 

  13. Davison, A. N., “Metabolism and Physiological Significance of Lipids,” R. M. C. Dawson and D. N. Rhodes, editors, John Wiley and Sons Inc., New York, 1964, p. 527–536.

    Google Scholar 

  14. Adams, C. W. M., and A. N. Davison, “Neurohistochemistry,” C. W. M. Adams, editor, Elsevier Publishing Company, Amsterdam, 1965, p 332–400.

    Google Scholar 

  15. Smith, M. E., and L. F. Eng, Proc. 6th Intern. Cong. Biochem., Vol. 7, New York, 1964, p 143.

    Google Scholar 

  16. Smith, M. E., and L. F. Eng, JAOCS42, 1013–1018 (1965).

    PubMed  CAS  Google Scholar 

  17. Eichberg, J., “Metabolism and Physiological Significance of Lipids,” R. M. C. Dawson and D. N. Rhodes, editor, John Wiley and Sons Inc., New York, 1964, p. 539.

    Google Scholar 

  18. Eichberg, J., and R. M. C. Dawson, Biochem. J.96, 644–650 (1965).

    PubMed  CAS  Google Scholar 

  19. Horrocks, L. A. R., J. Meckler and R. Collins, “Variation in Chemical Composition of the Nervous System”, G. B. Ansell, editor, Pergamon Press, New York, 1966, p 46.

    Google Scholar 

  20. Smith, M. E., R. Fumagalli and R. Paoletti, Life Sci.6, 1085–1091 (1967).

    Article  PubMed  CAS  Google Scholar 

  21. Banik, N. L., and A. N. Davison, J. Neurochem.14, 594–596 (1967).

    Article  PubMed  CAS  Google Scholar 

  22. Gerstl, B., L. J. Rubinstein, L. F. Eng and M. Tavaststjerna, Arch. Neurol.15, 603–614 (1966).

    PubMed  CAS  Google Scholar 

  23. Davison, A. N., M. L. Cuzner, N. L. Banik and J. Oxberry, Nature212, 1373–1374 (1966).

    Article  PubMed  CAS  Google Scholar 

  24. Laatsch, R. H., M. W. Kies, S. Gordon and E. C. Alvord Jr., J. Exp. Med.115, 777–788 (1962).

    Article  CAS  PubMed  Google Scholar 

  25. Lowry, O. H., N. J. Rosebrough, A. L. Farr and R. J. Randall, J. Biol. Chem.193, 265–275 (1951).

    PubMed  CAS  Google Scholar 

  26. Folch, J., M. Lees and G. H. Sloane Stanley, Ibid.226, 497–509 (1957).

    PubMed  CAS  Google Scholar 

  27. Rouser, G., G. Kritchevsky, D. Heller and E. Lieber, JAOCS40, 425–454 (1963).

    Google Scholar 

  28. Bartlett, G. R., J. Biol. Chem.234, 466–468 (1959).

    PubMed  CAS  Google Scholar 

  29. O'Brien J., E. L. Sampson and M. B. Stern, J. Neurochem.14, 357–365 (1967).

    Article  PubMed  Google Scholar 

  30. Eng, L. F., B. Gerstl, D. Pratt and M. G. Tavaststjerna, Abst., 1st International Meeting of International Soc. Neurochem., Strasbourg July, 1967.

  31. Finean, J. B., Experientia9, 17–19 (1953).

    Article  PubMed  CAS  Google Scholar 

  32. Vandenheuvel, F. A., JAOCS40, 455–471 (1963).

    Google Scholar 

  33. Eng, L. F., and M. E. Smith, Lipids1, 296 (1966).

    Article  CAS  PubMed  Google Scholar 

  34. Horrocks, L. A., J. Neurochem. In press. (1968).

  35. Horrocks, L. A., J. Lipid Res.8, 569–576 (1967).

    PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Veterans Administration Hospital, 94304, Palo Alto, California

    Lawrence F. Eng

  2. Department of Psychiatry, Stanford University School of Medicine, 94304, Palo Alto, California

    Ernest P. Noble

Authors
  1. Lawrence F. Eng
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  2. Ernest P. Noble
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Additional information

A preliminary report was given at the Federation of Western Societies of Neurological Sciences, March 3–6, 1966, San Francisco, Calif.

Career Development Awardee of the National Institute of Mental Health.

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Eng, L.F., Noble, E.P. The maturation of rat brain myelin. Lipids 3, 157–162 (1968). https://doi.org/10.1007/BF02531734

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  • DOI: https://doi.org/10.1007/BF02531734

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