Abstract
Studies on the transport of exogenous and endogenous cholesterol in the baboon have been carried out using14C-acetate,14C-mevalonic acid, or3H-cholesterol. The results suggest the following characteristics of cholesterol metabolism in the baboon: the serum α- and β-lipoproteins show no preference in the transport of exogenous or endogenous cholesterol; the half-life (t1/2) of disappearance of cholesterol from the whole animal varied between 31 and 50 days; the daily rate of whole body cholesterol biosynthesis in the baboon (47 mg/kg/day) is comparable with that rate observed in the human being (18–41 mg/kg/day); after administration of14C-acetate,14C-mevalonic acid, or3H-cholesterol to baboons, newly synthesized cholesterol esters appear to be incorporated to a greater extent into the serum α-lipoproteins.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Shapiro, I. L., and D. Kritchevsky, “The Baboon in Medical Research,” Vol. 1, H. Vagtborg (ed.), U. of Texas Press, Austin, 1965, p. 339.
Shapiro, I. L., J. A. Jastremsky, D. Kritchevsky and D. A. Eggen, “The Baboon in Medical Research,” Vol. 2, H. Vagtborg, (ed.), U. of Texas Press, Austin, 1967, p. 571.
Sperry, W. M., and M. Webb, J. Biol. Chem.187, 97–110 (1950).
Castaigne, A., and A. Amselem, Ann. Biol. Clin.17, 336–347 (1959).
Shapiro, I. L., and D. Kritchevsky, Analyt. Biochem.5, 88–91 (1963).
Gidez, L. I., and H. A. Eder, “First International Pharmacological Meeting, Vol. 2, Effects of Drugs on Synthesis and Mobilization of Lipids,” E.C. Horning and P. Lindgren (eds.), Pergamon Press, New York, 1963, p. 67.
Strong, J. P., J. Rosal, R. H. Deupree, and H. C. McGill Jr., Exp. Mol. Path.5, 82–91 (1966).
Van Zyl A., and J. E. Kerrich, Sth Afr. J. Med. Sci.20, 97–117 (1955).
Howard, A. N., G. A. Gresham, C. Richards and D. E. Bowyer, “The Baboon in Medical Research,” Vol. 1, H. Vagtborg (ed.), U. of Texas Press, Austin, 1966, p. 283.
Kritchevsky, D., E. S. Kritchevsky, P. P. Nair, J. A. Jastremsky and I. L. Shapiro, “Nutritio et Dieta,” in press (1967).
Shapiro, I. L., J. A. Jastremsky, D. A. Eggen and D. Kritchevsky, manuscript submitted to Life Sciences.
Goodman, DeW. S., J. Clin. Invest.43, 2026–2036 (1964).
Gidez, L. I., H. A. Eder, and W. W. Shreeve, Red Proc.17, 228 (1958).
Kurland, G. S., J. L. Lucas, and A. S. Freedberg, J. Lab. Clin. Med.57, 574–585 (1961).
Chobanian, A. V., B. A. Burrows, and W. Hollander, J. Clin. Invest.41, 1738–1744 (1962).
Casdorph, H. R., J. L. Juergens, A. L. Orvis and C. A. Owen Jr., Proc. Soc. Exp. Biol. and Med.112, 191–194 (1963).
Eggen, D. A., W. P. Newman, and J. P. Strong, “The Baboon in Medical Research,” Vol. 2, H. Vagtborg (ed.), U. of Texas Press, Austin, 1967, p. 559.
Shapiro, I. L., J. A. Jastremsky, and D. Kritchevsky, Life Sci.5, 1423–1429 (1966).
Glomset, J. A., E. T. Janssen, R. Kennedy, and J. Dobbins, J. Lipid Res.7, 639–648 (1966).
Author information
Authors and Affiliations
About this article
Cite this article
Shapiro, I.L., Jastremsky, J.A., Eggen, D.A. et al. Cholesterol metabolism in the baboon. Lipids 3, 136–142 (1968). https://doi.org/10.1007/BF02531730
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02531730