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The synthesis of14C- and3H-labeled glycerol ethers

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Lipids

Abstract

The racemic14C-and3H-labeled alpha and beta derivatives of octadecyl glycerol ether (batyl alcohol) and of hexadecyl glycerol ether (chimyl alcohol) of high specific activity were synthesized by treating the appropriate alkyl halides with a large excess of the potassium salts of isopropylidene or benzylidene glycerol. By use of the trifluoroacetic anhydride esterification procedure, the labeled diesters of alpha and beta octadecyl and hexadecyl glycerol ethers were prepared. The labeled monoesters of beta octadecyl and of beta hexadecyl glycerol ethers were isolated from the reaction mixtures by silicic acid column chromatography.

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Authors and Affiliations

  1. Departments of Biochemistry and Medicinal Chemistry, University of North Carolina, Chapel Hill, North Carolina

    Edward O. Oswald, Claude Piantadosi, Carl E. Anderson & Fred Snyder

  2. The Medical Division, Oak Ridge Institute of Nuclear Studies, Oak Ridge Associated Universities, Oak Ridge, Tennessee

    Edward O. Oswald, Claude Piantadosi, Carl E. Anderson & Fred Snyder

Authors
  1. Edward O. Oswald
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  2. Claude Piantadosi
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  3. Carl E. Anderson
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  4. Fred Snyder
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Additional information

Work done in partial fulfillment for PhD Degree, Department of Biochemistry, University of North Carolina.

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Oswald, E.O., Piantadosi, C., Anderson, C.E. et al. The synthesis of14C- and3H-labeled glycerol ethers. Lipids 1, 241–246 (1966). https://doi.org/10.1007/BF02531609

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  • DOI: https://doi.org/10.1007/BF02531609

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