, Volume 1, Issue 4, pp 237–240 | Cite as

Lipid synthesis in peripheral nerve from alloxan diabetic rats

  • Sven G. Eliasson


Decreased conduction velocity in the peripheral nerves of rats is noted after induction of diabetes. The slowing of nerve conduction is accompanied by a decrease in the in vitro incorporation of radioactive precursors into some of the myelin lipids isolated from nerve segments. Cerebroside synthesis is more depressed than that of any other fraction. A change in the type of cerebrosides synthesized is seen with a pronounced decrease in the rate of incorporation of saturated fatty acids.


Sciatic Nerve Alloxan Nerve Segment Mercuric Acetate Normal Fatty Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Eliasson, S.G., J. Clin. Invest.43, 2353–2358 (1964).PubMedCrossRefGoogle Scholar
  2. 2.
    Mayer, R.F., Neurology (Minneap.)13, 1021–1030 (1963).Google Scholar
  3. 3.
    Eliasson, S.G., Progr. Amer. Acad. Neurol. Vol.10, 23 (1960).Google Scholar
  4. 4.
    Goldman, P., and P. R. Vagelos, J. Biol. Chem.236, 2620–2623 (1961).PubMedGoogle Scholar
  5. 5.
    Carter, H.E., and Y. Fujino, J. Biol. Chem.221, 879–884 (1956).PubMedGoogle Scholar
  6. 6.
    Klebanoff, S.J., and A.L. Greenbaum, J. Endocrinal11, 314–322 (1954).Google Scholar
  7. 7.
    Folch, J., M. Lees and G.H.S. Stanley, J. Biol. Chem.226, 497–509 (1957).PubMedGoogle Scholar
  8. 8.
    Hirsch, J., and E.H. Ahrens Jr., J. Biol. Chem.233, 311–320 (1958).PubMedGoogle Scholar
  9. 9.
    Kishimoto, Y., and N.S. Radin, J. Lipid Res.3, 327–332 (1962).Google Scholar
  10. 10.
    Hajra, A.K., and N.S. Radin, J. Lipid Res.3, 327–332 (1962).Google Scholar
  11. 11.
    Radin, N.S., J.R. Brown and F.B. Lavin, J. Biol. Chem.219, 977–983 (1956).PubMedGoogle Scholar
  12. 12.
    Wagner, H., L. Hörhammer and P. Wolff, Biochem. Z.334, 175–184 (1961).PubMedGoogle Scholar
  13. 13.
    Reitsema, R.H., Anal. Chem.26, 960–963 (1954).CrossRefGoogle Scholar
  14. 14.
    Bray, G.A., Anal. Biochem.1, 279–285 (1960).CrossRefGoogle Scholar
  15. 15.
    Johnson, A.C., A.R. McNabb and R.J. Rossiter, Biochem. J.45, 500–508 (1949).PubMedGoogle Scholar
  16. 16.
    Berry, J.F., W.H. Cevallos and R.R. Wade Jr. JAOCS42, 492–500 (1965).PubMedGoogle Scholar
  17. 17.
    Eliasson, S. G., Unpublished results.Google Scholar
  18. 18.
    Cumings, J.N., in “Biochemical Aspects of Neurological Disorders”, J. N. Cumings and M. Kremer, Editors, Blackwell Scientific Publications, Oxford, 1959, p 180–190.Google Scholar
  19. 19.
    Burton, R.M., M.A. Sodd and R.O. Brady, J. Biol. Chem.233, 1053–1060 (1958).PubMedGoogle Scholar
  20. 20.
    Brady, R.O., J. Biol. Chem.237, PC2416-PC2417 (1962).Google Scholar
  21. 21.
    Erwin, J., and K. Bloch, Science143, 1006–1012 (1964).PubMedCrossRefGoogle Scholar
  22. 22.
    Gerstl, B., N. Malamud, R. B. Hayman and P.R. Bond, J. Neurol. Neurosurg. Psych. 28: 540–547 (1965).CrossRefGoogle Scholar
  23. 23.
    Adams, L.C., and R.A. Field, Proc. Fifth. Congr. Int. Diab. Fed., Excerpta Med. Int. Congr. Ser. No. 74, (1964), p. 50.Google Scholar
  24. 24.
    Gabbay, K.H., L.O. Merola and R.A. Field, Science151, 209–210 (1966).PubMedCrossRefGoogle Scholar
  25. 25.
    Stewart, M.A., W.R. Sherman and S. Anthony, Biochem. Biophys. Res. Comm.22, 488–491 (1966).CrossRefGoogle Scholar

Copyright information

© American Oil Chemists’ Society 1966

Authors and Affiliations

  • Sven G. Eliasson
    • 1
    • 2
  1. 1.Department of NeurologyWashington University, School of MedicineSt. Louis
  2. 2.The Beaumont-May Institute of NeurologyWashington University, School of MedicineSt. Louis

Personalised recommendations