Abstract
Decreased conduction velocity in the peripheral nerves of rats is noted after induction of diabetes. The slowing of nerve conduction is accompanied by a decrease in the in vitro incorporation of radioactive precursors into some of the myelin lipids isolated from nerve segments. Cerebroside synthesis is more depressed than that of any other fraction. A change in the type of cerebrosides synthesized is seen with a pronounced decrease in the rate of incorporation of saturated fatty acids.
Similar content being viewed by others
References
Eliasson, S.G., J. Clin. Invest.43, 2353–2358 (1964).
Mayer, R.F., Neurology (Minneap.)13, 1021–1030 (1963).
Eliasson, S.G., Progr. Amer. Acad. Neurol. Vol.10, 23 (1960).
Goldman, P., and P. R. Vagelos, J. Biol. Chem.236, 2620–2623 (1961).
Carter, H.E., and Y. Fujino, J. Biol. Chem.221, 879–884 (1956).
Klebanoff, S.J., and A.L. Greenbaum, J. Endocrinal11, 314–322 (1954).
Folch, J., M. Lees and G.H.S. Stanley, J. Biol. Chem.226, 497–509 (1957).
Hirsch, J., and E.H. Ahrens Jr., J. Biol. Chem.233, 311–320 (1958).
Kishimoto, Y., and N.S. Radin, J. Lipid Res.3, 327–332 (1962).
Hajra, A.K., and N.S. Radin, J. Lipid Res.3, 327–332 (1962).
Radin, N.S., J.R. Brown and F.B. Lavin, J. Biol. Chem.219, 977–983 (1956).
Wagner, H., L. Hörhammer and P. Wolff, Biochem. Z.334, 175–184 (1961).
Reitsema, R.H., Anal. Chem.26, 960–963 (1954).
Bray, G.A., Anal. Biochem.1, 279–285 (1960).
Johnson, A.C., A.R. McNabb and R.J. Rossiter, Biochem. J.45, 500–508 (1949).
Berry, J.F., W.H. Cevallos and R.R. Wade Jr. JAOCS42, 492–500 (1965).
Eliasson, S. G., Unpublished results.
Cumings, J.N., in “Biochemical Aspects of Neurological Disorders”, J. N. Cumings and M. Kremer, Editors, Blackwell Scientific Publications, Oxford, 1959, p 180–190.
Burton, R.M., M.A. Sodd and R.O. Brady, J. Biol. Chem.233, 1053–1060 (1958).
Brady, R.O., J. Biol. Chem.237, PC2416-PC2417 (1962).
Erwin, J., and K. Bloch, Science143, 1006–1012 (1964).
Gerstl, B., N. Malamud, R. B. Hayman and P.R. Bond, J. Neurol. Neurosurg. Psych. 28: 540–547 (1965).
Adams, L.C., and R.A. Field, Proc. Fifth. Congr. Int. Diab. Fed., Excerpta Med. Int. Congr. Ser. No. 74, (1964), p. 50.
Gabbay, K.H., L.O. Merola and R.A. Field, Science151, 209–210 (1966).
Stewart, M.A., W.R. Sherman and S. Anthony, Biochem. Biophys. Res. Comm.22, 488–491 (1966).
Author information
Authors and Affiliations
About this article
Cite this article
Eliasson, S.G. Lipid synthesis in peripheral nerve from alloxan diabetic rats. Lipids 1, 237–240 (1966). https://doi.org/10.1007/BF02531608
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02531608