Lipids

, Volume 5, Issue 7, pp 658–661 | Cite as

Inhibition of renal cortical Rb+ transport by phospholipase C and its relationship to (Na++K+)-adenosine triphosphatase

  • Amra Malila
  • Edward J. Masoro
Short Communications

Abstract

Treatment of isolated renal cortical tubules with a low concentration of phospholipase C (one which does not lead to a chemically detectable loss of tubular phospholipid) results in a markedly inhibited Rb+ transport function which is referable to the loss of a phospholipid component of the tubules. This treatment also results in an inhibition of the (Na++K+)-adenosine triphosphatase enzyme of the tubules. The data are consistent with the concept that it is the loss in (Na++K+)-adenosine triphosphatase activity which is responsible for phospholipase C-induced inhibition of Rb+ transport.

Keywords

Vinyl Ether Adenosine Triphosphatase Glyceryl Ether Lithium Aluminum Hydride Thin Layer Chro 

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Copyright information

© American Oil Chemists’ Society 1969

Authors and Affiliations

  • Amra Malila
    • 1
  • Edward J. Masoro
    • 1
  1. 1.Department of Physiology and BiophysicsWoman’s Medical College of PennsylvaniaPhiladelphia

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