Phase relationships involving the deposition of cholesterol from triglyceride solution
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Adsorption isotherms describing the adsorption of cholesterol from solution in various oils by Permutit were investigated. Multiple layer adsorption onto Permutit and cholesterol crystallization from solutions that would have been subsaturated with respect to cholesterol in the absence of Permutit were observed. Association of cholesterol with Permutit, required for multiple layer adsorption, was observed even at low concentrations of cholesterol. Near infrared absorption spectra of solutions of cholesterol revealed marked aggregation of cholesterol in solutions of greater than about 0.2 M. Thus, association with Permutit apparently initiates crystallization and the similar aggregation of cholesterol in solution and in the solid phase apparently propagates the crystallization of cholesterol. Hydrogen bonding of cholesterol to the ester bond of triglycerides is unrelated to solubility of cholesterol in triglycerides examined.
KeywordsCholesterol Adsorption Isotherm Cholesterol Concentration Methyl Oleate Ester Bond
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