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Lipids

, Volume 4, Issue 6, pp 413–420 | Cite as

Endocrine control of fat mobilization in the isolated fat cells of cold-exposed rats

  • Donald G. Therriault
  • Roger W. Hubbard
  • Donald B. Mellin
Article

Abstract

Adipose tissue in rats maintained at normal ambient temperature grows by a mixture of cell proliferation and lipid deposition in the early growth stage of the rat. In the mature rat, the tissue grows primarily by lipid deposition, mitotic activity being significantly decreased. When the rat is acclimated to 5 C, growth of adipose tissue is less than that of rats maintained at normal ambient temperature. Furthermore, growth of adipose tissue in the 5 C rat occurs through a mixture of cell proliferation and lipid deposition throughout the body weight range studied. The differences in tissue growth were taken into consideration in measuring the stimulatory effect of norepinephrine on lipolysis and reesterification of isolated fat cells. The results indicate that the cell size affects the lipolytic response; the larger the cell the less sensitive it is. Fat cells from cold-acclimated rats are more sensitive to the lipolytic action of norepinephrine, independent of differences in cell size. On the other hand, reesterification is not affected by cell size, nor by exposure of the rat to cold

Keywords

Adipose Tissue Adipose Tissue Mass Normal Ambient Temperature Ringer Phosphate Buffer Normal Ambient Tempera 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The American Oil Chemists’ Society 1969

Authors and Affiliations

  • Donald G. Therriault
    • 1
  • Roger W. Hubbard
    • 1
  • Donald B. Mellin
    • 1
  1. 1.Biochemistry-Pharmacology LaboratoryU.S. Army Research Institute of Environmental MedicineNatick

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