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Isotope dilution assay for dexamethasone in pharmaceutical preparations

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Abstract

The determination of 9-α-fluoro-16-α-methylprednisolone (dexamethasone) in drugs using isotope dilution method is described. Dexamethasone is tritiated with tritium-labelled acetic acid and in the course of the isotopic dilution the activity of tritium is measured with a liquid scintillator.

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References

  1. C. Rosenblum, A. M. Gerber, H. T. Meriwether andH. E. Mertel, Abstracts, Second International Conference on Methods of Preparing and Storing Labelled Compounds, Euratom, Brussels 1966, p. 79.

  2. A. M. Rutenburg, R. Gofstein, andA. M. Seligman,Cancer Res. 10 (1950) 113.

    CAS  Google Scholar 

  3. W. J. Mader andR. R. Buck,Anal. Chem., 24 (1952) 666.

    Article  CAS  Google Scholar 

  4. C. Rosenblum,Anal. Chem., 29 (1957) 1740.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Merck Sharp & Dohme Research Laboratories, Division of Merck & Co., Inc., Rahway, N. J., U.S.A.

    C. Rosenblum & H. T. Meriwether

Authors
  1. C. Rosenblum
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  2. H. T. Meriwether
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Rosenblum, C., Meriwether, H.T. Isotope dilution assay for dexamethasone in pharmaceutical preparations. J. Radioanal. Chem. 1, 163–167 (1968). https://doi.org/10.1007/BF02530236

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  • DOI: https://doi.org/10.1007/BF02530236

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