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MHC class II+ keratinocytes from IFNγ-treated human skin activate T cells in the presence of staphylococcal superantigen despite UVB irradiation

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References

  1. Austad J, Braathen LR (1985) Effect of UVB on alloactivating and antigen-presenting capacity of human epidermal Langerhans cells. Scand J Immunol 21:417–423

    Article  PubMed  CAS  Google Scholar 

  2. Baadsgaard O, Lisby S, Wantzin GL, Wulf HC, Cooper KD (1989) Rapid recovery of Langerhans cell alloreactivity, without induction of autoreactivity, after in vivo ultraviolet A, but not ultraviolet B exposure of human skin. J Immunol 142: 4213–4218

    PubMed  CAS  Google Scholar 

  3. Barker JNWN, Allen MH, Macdonald DM (1990) Alterations induced in normal human skin by in vivo interferon-gamma. Br J Dermatol 122:451–458

    Article  PubMed  CAS  Google Scholar 

  4. Buslau M, Kappus R, Gerlach D, Köhler W, Diehl S, Holzmann H (1993) Streptococcal and staphylococcal superantigens (ETA, SEB): presentation by human epidermal cells and induction of autologous T cell proliferation in vitro. Acta Derm Venereol (Stockh) 73:94–96

    CAS  Google Scholar 

  5. Cooper KD, Fox P, Neises G, Katz SI (1985) Effects of ultraviolet radiation on human epidermal cell alloantigen presentation: initial depression of Langerhans cell-dependent function is followed by the appearance of T6- DR+ cells that enhance epidermal alloantigen presentation. J Immunol 134:129–137

    PubMed  CAS  Google Scholar 

  6. Cooper KD, Neises GR, Katz SI (1986) Antigen-presenting OKM5+ melanophages appear in human epidermis after ultraviolet radiation. J Invest Dermatol 86:363–370

    Article  PubMed  CAS  Google Scholar 

  7. Leyden JJ, Marples RR, Kligman AM (1974)Staphylococcus aureus in the lesions of atopic dermatitis. Br J Dermatol 90: 525–530

    Article  PubMed  CAS  Google Scholar 

  8. Marples RR, Heaton CL, Kligman AM (1973)Staphylococcus aureus in psoriasis. Arch Dermatol 107:568–570

    Article  PubMed  CAS  Google Scholar 

  9. Mcfadden JP, Noble WC, Camp RDR (1993) Superantigenic exotoxin-secreting potential of staphylococci isolated from atopic eczematous skin. Br J Dermatol 128:631–632

    Article  PubMed  CAS  Google Scholar 

  10. Skov L, Strange P, Baadsgaard O (1994) Staphylococcal superantigens applied on intact human skin resulted in development of dermatitis (abstract). J Invest Dermatol 102:628

    Google Scholar 

  11. Strange P, Skov L, Baadsgaard O (1994) Interferon-gammatreated keratinocytes activate T cells in the presence of superantigens: involvement of major histocompatibility complex class II molecules. J Invest Dermatol 102:150–154

    Article  PubMed  CAS  Google Scholar 

  12. Volc-Platzer B, Majdic O, Knapp W, Wolff K, Hinterberger W, Lechner K, Stingl G (1984) Evidence of HLA-DR antigen biosynthesis by human keratinocytes in disease. J Exp Med 159: 1784–1789

    Article  PubMed  CAS  Google Scholar 

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Skov, L., Baadsgaard, O. MHC class II+ keratinocytes from IFNγ-treated human skin activate T cells in the presence of staphylococcal superantigen despite UVB irradiation. Arch Dermatol Res 288, 255–257 (1996). https://doi.org/10.1007/BF02530095

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  • DOI: https://doi.org/10.1007/BF02530095

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