Advertisement

Archives of Dermatological Research

, Volume 288, Issue 5–6, pp 249–251 | Cite as

Prolonged nuclear accumulation of p53 in xeroderma pigmentosum complementation group A cells after ultraviolet irradiation

  • Shoji Kato
  • Yoshio Urano
  • Shiro Sasaki
  • Kamrul Ahsan
  • Masayuki Shono
  • Seiji Arase
Short Communication
  • 25 Downloads

Key words

Xeroderma pigmentosum p53 Immunostaining Ultraviolet irradiation 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Hollstein M, Sidransky D, Vogelstein B, Harris CC (1991) p53 mutations in human cancers. Science 253:49–53PubMedCrossRefGoogle Scholar
  2. 2.
    Kubo Y, Urano Y, Yoshimoto K, Iwahana H, Fukuhara K, Arase S, Itakura M (1994) p53 gene mutations in human skin cancers and precancerous lesions: comparison with immunohistochemical analysis. J Invest Dermatol 102:440–444PubMedCrossRefGoogle Scholar
  3. 3.
    Urano Y, Oura H, Sakaki A, Nagae H, Matsumoto K, Fukuhara K, Nagae T, Arase S, Ninomiya Y, Nakanishi H, Shigemi F, Takeda K (1992) Immunohistological analysis of p53 expression in human skin tumors. J Dermatol Sci 4:69–75PubMedCrossRefGoogle Scholar
  4. 4.
    Fritsche M, Haessler C, Brandner G (1993) Induction of nuclear accumulation of the tumor-suppressor protein p53 by DNA-damaging agents. Oncogene 8:307–318PubMedGoogle Scholar
  5. 5.
    Kuerbitz SJ, Plunkett BS, Walsh WV, Kastan MB (1992) Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc Natl Acad Sci USA 89:7491–7495PubMedCrossRefGoogle Scholar
  6. 6.
    Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T (1993) p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362:847–849PubMedCrossRefGoogle Scholar
  7. 7.
    Clarke AR, Purdie CA, Harrison DJ, Morris RG, Bird CC, Hooper ML, Wyllie AH (1993) Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 362:849–852PubMedCrossRefGoogle Scholar
  8. 8.
    Kraemer KH, Lee MM, Scotto J (1987) Xeroderma pigmentosum. Arch Dermatol 123:241–250PubMedCrossRefGoogle Scholar
  9. 9.
    Cleaver JE, Bootsma D (1975) Xeroderma pigmentosum: biochemical and genetic characteristics. Annu Rev Genet 9:19–38PubMedCrossRefGoogle Scholar
  10. 10.
    Lu X, Lane DP (1993) Differential induction of transcriptionally active p53 following UV or ionizing radiation: defect in chromosome instability syndrome. Cell 75:765–778PubMedCrossRefGoogle Scholar
  11. 11.
    Nelson W, Kastan M (1994) DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways. Mol Cell Biol 14:1815–1823PubMedGoogle Scholar
  12. 12.
    Yamaizumi M, Sugano T (1994) UV-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle. Oncogene 9:2775–2784PubMedGoogle Scholar
  13. 13.
    Sato K, Watatani M, Ikenaga M, Kozuka T, Kitano Y, Yoshikawa K, Mimaki T, Abe J, Sugita T (1987) Sensitivity to UV radiation of fibroblasts from a Japanese group A xeroderma pigmentosum patient with mild neurological abnormalities. Br J Dermatol 116:101–108PubMedCrossRefGoogle Scholar
  14. 14.
    Shono M, Yamada M, Yamaguchi H, Miyamoto H (1993) Aerobic responses of mouse macrophages to phagocytosis againstEsherichia coli as revealed by microphotometry. Cell Mol Biol 39:361–370PubMedGoogle Scholar
  15. 15.
    Halevy O, Hall A, Oren M (1989) Stabilization of the p53 transformation-related protein in mouse fibrosarcoma cell lines: effects of protein sequence and intracellular environment. Mol Cell Biol 9:3385–3392PubMedGoogle Scholar
  16. 16.
    Gannon JV, Greaves R, Iggo R, Lane DP (1990) Activating mutations in p53 produce a common conformational effect. A monoclonal antibody specific for the mutant form. EMBO J 9: 1595–1602PubMedGoogle Scholar
  17. 17.
    Hiramoto T, Matsunaga T, Ichihashi M, Nikaido O, Fujiwara Y, Mishima Y (1989) Repair of 254 nm ultraviolet-induced (6-4) photoproducts: monoclonal antibody recognition and differential defects in xeroderma pigmentosum complementation groups A, D, and variant. J Invest Dermatol 93:703–706PubMedCrossRefGoogle Scholar
  18. 18.
    Yonish-Rouach E, Resnitzky D, Lotem J, Sachs L, Kimchi A, Oren M (1991) Wild type p53 induces apoptosis of myeloid leukemia cells that is inhibited by interleukin-6. Nature 352: 345–347PubMedCrossRefGoogle Scholar
  19. 19.
    Shaw P, Bovey R, Tardy S, Sahli R, Sordat B, Costa J (1992) Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc Natl Acad Sci USA 89:4495–4499PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Shoji Kato
    • 1
  • Yoshio Urano
    • 1
  • Shiro Sasaki
    • 1
  • Kamrul Ahsan
    • 1
  • Masayuki Shono
    • 2
  • Seiji Arase
    • 1
  1. 1.Department of Dermatology, School of MedicineThe University of TokushimaTokushimaJapan
  2. 2.General Laboratories for Medical Research, School of MedicineThe University of TokushimaTokushimaJapan

Personalised recommendations