Adamantane derivatives: Pharmacological and toxicological properties (review)

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References

  1. 1.

    I. E. Kovalev, L. I. Durakova, M. I. Shmar'yan, et al.,Khim. -Farm. Zh.,11(20), 3–7 (1977).

    Google Scholar 

  2. 2.

    Yu. N. Klimochkin, I. K. Moiseev, G. V. Vadyko, et al.,Khim. -Farm. Zh.,25(7), 46–49 (1991).

    CAS  Google Scholar 

  3. 3.

    M. D. Mashkovskii,Drugs [in Russian], Meditsina, Moscow (1993), pp. 176–177.

    Google Scholar 

  4. 4.

    Z. E. Stolyarov, A. G. Fedorchuk, and L. A. Prishchepa,Khim. -Farm. Zh.,27(9), 4–8 (1993).

    CAS  Google Scholar 

  5. 5.

    I. M. Kamyanov and R. A. Andrezinya,Eksp. Klin. Farmakoterap. (Zinatne), No. 9, 105–110 (1980).

    Google Scholar 

  6. 6.

    J. Kornhuber, M. Weller, K. Schoppmeyer, et al.,J. Neural. Transm. Suppl.,43, 91–104 (1994).

    PubMed  CAS  Google Scholar 

  7. 7.

    W. H. Oertel and R. C. Dodel,Mov. Disord.,10(2), 121–131(1995).

    PubMed  CAS  Article  Google Scholar 

  8. 8.

    I. G. Kharitonenko, S. el Karadagi, A. N. Fedorov et al.,Vopr. Virusol.,33(1), 22–26 (1988).

    Google Scholar 

  9. 9.

    V. A. Tverdislov, S. el Karadagi, I. G. Kharitonenkov, et al.,Gen. Physiol. Biophys.,5(1), 61–75 (1986).

    PubMed  CAS  Google Scholar 

  10. 10.

    O. I. Kiselev, V. M. Blinov, K. N. Kozeletskaya, et al.,Vestn. Ross. Akad. Med. Nauk, No. 3, 10–15 (1993).

    PubMed  Google Scholar 

  11. 11.

    Z. E. Stolyarov and K. P. Lyashchenko,Khim. -Farm. Zh.,29(8), 9–10 (1995).

    CAS  Google Scholar 

  12. 12.

    C. Clark, M. M. Woodson, N. T. Nagasava,Immunopharmacology,21(1), 40–50 (1991).

    Article  Google Scholar 

  13. 13.

    A. V. Val'dman, M. M. Kozlovskaya, and S. K. Germane,Eksp. Klin. Farmakoterap. (Zinatne), No. 8, 142–154 (1979).

    Google Scholar 

  14. 14.

    A. M. Zharkovskii,Farmakol. Toksikol., No. 5, 517–521 (1977).

    Google Scholar 

  15. 15.

    A. M. Zharkovskii, S. Ya. Mark, and L. Kh. Allikmets,Proc. Meet. on Current Problems in Neuropharmacology [in Russian], Tartu (1973), pp. 53–56.

  16. 16.

    G. W. VollerDt. Med. Wovh. -Shcr.,95(17), 934 (1974).

    Google Scholar 

  17. 17.

    L. Kh. Allikmets and A. A. Ross,Proc. Meet. on the Current Problems in Neuropharmacology [in Russian], Tartu (1973), pp. 92–96.

  18. 18.

    A. M. Zharkovskii, S. Ya. Mark, and L. Kh. Allikmets, in:Problems in the Pharmacology of Neurotropic Drugs [in Russian], Zinatne, Riga (1974), pp. 43–46.

    Google Scholar 

  19. 19.

    S. V. Krapivin, S. A. Sergeeva, I. S. Morozov, et al.,Byul. Eksp. Biol. Med., No. 7, 57–59 (1991).

    Google Scholar 

  20. 20.

    M. Weller, F. Finiels Marlier, and S. M. Paul,Brain. Res.,613(1), 143–148 (1993).

    PubMed  CAS  Article  Google Scholar 

  21. 21.

    J. Kornhuber, K. Schoppmeyer, and R. Riederer,Neurosci. Lett.,163(2), 129–131 (1993).

    PubMed  CAS  Article  Google Scholar 

  22. 22.

    I. Bresink, W. Danysz, C. G. Parsons, et al.,Neuropharmacology,34(5), 533–540 (1995).

    PubMed  CAS  Article  Google Scholar 

  23. 23.

    V. Kunzelmann,Fortschr. Med.,111(27), 423–425 (1993).

    PubMed  CAS  Google Scholar 

  24. 24.

    M. G. Garrino and J. C. Henquin,Br. J. Pharmacol.,90(3), 583–591 (1987).

    PubMed  CAS  Google Scholar 

  25. 25.

    N. F. Pravdina, S. G. Tul'kes, V. M. Shobukhov, et al.,Vopr. Virusol., No. 2, 208–209 (1982).

    Google Scholar 

  26. 26.

    C. Koppel and J. Tenczer,Biomed. Mass. Spectrom.,12(9), 499–501 (1985).

    PubMed  CAS  Article  Google Scholar 

  27. 27.

    S. A. Sergeeva and L. M. KrasnykhEksp. Klin. Farmakol.,57(3), 69–74 (1994).

    PubMed  CAS  Google Scholar 

  28. 28.

    M. M. Zhiravetskii, N. A. Leont'eva, I. A. Vinograd, et al.,Vopr. Med. Khim.,32(6), 118–120 (1986).

    PubMed  CAS  Google Scholar 

  29. 29.

    G. A. Galegov and V. M. Zhukov,Vestn. Akad. Med. Nauk SSSR, No. 3, 77–81 (1976).

    PubMed  Google Scholar 

  30. 30.

    F. G. Hayden, A. Minocha, D. A. Spyker, et al.,Antimicrob. Agents Chemother.,28(2), 216–221 (1985).

    PubMed  CAS  Google Scholar 

  31. 31.

    R. L. Tominack and F. G. Hayden,Infect. Dis. Clin. North. Am.,1(2), 459–478 (1987).

    PubMed  CAS  Google Scholar 

  32. 32.

    E. Donath, A. Herrmann, W. T. Coakley, et al.,Biochem. Pharmacol.,36(4), 481–487 (1987).

    PubMed  CAS  Article  Google Scholar 

  33. 33.

    S. K. Germane,Eksp. Klin. Farmakoterap. (Zinatne), No. 15, 6–13 (1986).

    CAS  Google Scholar 

  34. 34.

    S. V. Krapivin and I. S. Morozov,Eksp. Klin. Farmakol.,57(5), 66–72 (1994).

    PubMed  CAS  Google Scholar 

  35. 35.

    R. A. Andrezinya,Author's Abstract of Cand. Sci. (Med. Sci.) Thesis [in Russian], Tartu (1973), pp. 92–96.

  36. 36.

    R. O. Vitalin' and A. A. Kimenis,Eksp. Klin. Farmakoterap. (Zinatne), No. 9, 99–104 (1980).

    Google Scholar 

  37. 37.

    S. K. Germane, M. M. Krima, D. A. Berzinya, et al.,Directed Search for New Neurotropic Preparations [in Russian], Zinatne Riga (1983), pp. 42–59.

    Google Scholar 

  38. 38.

    H. S. Chen, J. W. Pellegrini, S. K. Aggarwal, et al.,J. Neurosci.,12(11), 4427–4436 (1992).

    PubMed  CAS  Google Scholar 

  39. 39.

    J. M. Rabey, P. Nissipeanu, A. D. Korczyn,J. Neural. Transm. Park. Dis. Dement. Sect., No. 4, 277–282 (1992).

    PubMed  CAS  Article  Google Scholar 

  40. 40.

    E. Eisenberg, B. P. Vos, A. M. Strassman,Pain 54(3), 301–307 (1993).

    PubMed  CAS  Article  Google Scholar 

  41. 41.

    K. Masuo, R. Enomoto, N. Maeno,Eur. J. Pharmacol.,130(3), 187–195 (1986).

    PubMed  CAS  Article  Google Scholar 

  42. 42.

    I. S. Morozov, V. G. Barchukov, N. P. Bykov, et al.,Abstracts of Papers. The 1st Meet. All-Russia Sci. Soc. Pharmacologists (9–13 October, 1995) [in Russian], Moscow (1995), p. 291.

  43. 43.

    I. S. Morozov, N. V. Klimova, N. I. Avdyunina, et al.,Abstracts of Papers. The 7th Sci. -Pract. Conf. of CIS Countries “Prospects in Development of the Chemistry and Applications of Framework Compounds” (5–7 September, 1995) [in Russian], Volgograd (1995), p. 166–167.

  44. 44.

    S. A. Sergeeva, V. V. Khoron'ko, L. M. Krasnykh, et al.,Abstracts of Papers. The 1st Meet. All-Russia Sci. Soc. Pharmacologists (9–13 October, 1995) [in Russian], Moscow (1995), p. 389.

  45. 45.

    T. V. Grekhova, R. R. Gainetdinov, T. D. Sotnikova, et al.,Byul. Eksp. Biol. Med., No. 3, 302–304 (1995).

    Google Scholar 

  46. 46.

    A. A. Spasov, L. I. Bugaeva, I. N. Yozhitsa, et al.,Farmakoterapiya,1/2(3), 86 (1997).

    Google Scholar 

  47. 47.

    S. V. Krapivin, S. A. Sergeeva, I. S. Morozov,Byul. Eksp. Biol. Med.,116(11), 515–518 (1993).

    CAS  Google Scholar 

  48. 48.

    T. S. Galushkina, T. A. Fadeeva, and N. G. Artsimovich,Immunologiya, No. 4, 28–30 (1996).

    Google Scholar 

  49. 49.

    L. M. Krasnykh and S. A. Sergeeva,Abstracts of Papers. The 7th Sci. -Pract. Conf. of CIS Countries “Prospects in Development of the Chemistry and Applications of Framework Compounds” (5–7 September, 1995) [in Russian], Volgograd (1995), pp. 170–171.

  50. 50.

    S. A. Sergeeva and L. M. Krasnykh,Khim. -Farm. Zh.,29(4), 28–29 (1995).

    Google Scholar 

  51. 51.

    N. G. Artsimovich, T. A. Fadeeva, Yu. A. Shalyminova, USSR Inventor's Certificate No. 1 586 711;Byul. Izobret., No. 31 (1990).

  52. 52.

    E. M. Rekalova,Vrach. Delo, No. 4, 73–76 (1992).

    Google Scholar 

  53. 53.

    V. M. Man'ko, B. V. Pinegin, T. V. Rudneva, et al.,Zh. Mikrobiol., Epidemiol. Immunobiol., No. 9, 66–67 (1991).

    Google Scholar 

  54. 54.

    V. M. Man'ko, B. V. Pinegin, T. V. Rudneva, et al.,Zh. Mikrobiol., Epidemiol. Immunobiol., No. 9, 6–65 (1991).

    Google Scholar 

  55. 55.

    S. S. Boiko, V. P. Zherdev, and N. A. Kislyak,Farmakol. Toksikol., No. 1, 57–60 (1991).

    Google Scholar 

  56. 56.

    S. S. Boiko, V. P. Zherdev, and N. A. Kislyak,Khim. -Farm. Zh.,25(1), 76–78 (1991).

    CAS  Google Scholar 

  57. 57.

    S. S. Boiko, V. P. Zherdev, N. A. Kislyak, et al.,Eksp. Klin. Farmakol.,57(6), 48–50 (1994).

    PubMed  CAS  Google Scholar 

  58. 58.

    V. P. Zherdev, S. S. Boiko, N. A. Kislyak, et al.,Khim. -Farm. Zh.,29(1), 32–34 (1995).

    CAS  Google Scholar 

  59. 59.

    D. A. Kharkevich,Farmakol. Toksikol. No. 5, 531–536 (1970).

    Google Scholar 

  60. 60.

    E. P. Svadzhan and V. V. Shitov,Eksp. Khir., No. 6, 62–66 (1975).

    Google Scholar 

  61. 61.

    V. A. Mikel'son, L. E. Tsypin, A. P. Makarov, et al.,Vestn. Akad. Med. Nauk SSSR, No. 2, 77–80 (1977).

    Google Scholar 

  62. 62.

    V. Yu. Ostrovskii and S. D. Kiselev,Anesteziol. Revmatol., No. 3, 7–10 (1080).

    Google Scholar 

  63. 63.

    V. P. Fisenko,Author's Abstract of Cand. Sci. (Med. Sci.) Thesis [in Russian], Moscow (1971), p. 14.

  64. 64.

    D. A. Kharkevich and A. P. Skoldinov,Dokl. Akad. Nauk SSSR,198(4), 984–987 (1971).

    Google Scholar 

  65. 65.

    E. N. Pershin,Farmakol. Toksikol., No. 5, 517–527 (1975).

    Google Scholar 

  66. 66.

    M. K. Indulen, I. A. Kenal', G. M. Ryazantseva, et al.,Izv. Akad. Nauk LatSSR, No. 9, 88–97 (1972).

    Google Scholar 

  67. 67.

    G. Fytas, P. Marakos, N. Kolocouris, et al.,Farmaco,49(10), 641–647 (1994).

    PubMed  CAS  Google Scholar 

  68. 68.

    G. I. Danilenko, V. I. Votyakov, O. T. Andreeva, et al.,Khim. -Farm. Zh.,11(5), 71–73 (1977).

    CAS  Google Scholar 

  69. 69.

    S. G. Markushin, B. V. Sinitsyn, V. P. Ginzburg, et al.,Vopr. Virusol.,38(3), 122–126 (1993).

    PubMed  CAS  Google Scholar 

  70. 70.

    L. L. Stotskaya, A. V. Serbin, K. Munshi, et al.,Khim. -Farm. Zh.,29(3), 19–22 (1995).

    CAS  Google Scholar 

  71. 71.

    A. Papadaki Valiraki, S. Papakonstantinou Garoufalias, P. Marakos, et al.,Farmacol.,48(8), 1091–1102 (1993).

    CAS  Google Scholar 

  72. 72.

    I. A. Novakov, V. P. Petrov, B. S. Orlinson, et al.,Khim. -Farm. Zh.,30(2), 22–24 (1996).

    CAS  Google Scholar 

  73. 73.

    S. K. Germane, Ya. Yu. Polis, and L. Ya. Karinya,Khim. -Farm. Zh.,11(3), 66–70 (1977).

    CAS  Google Scholar 

  74. 74.

    L. G. Magazinik, S. M. Antonov, N. Ya. Lukomskaya, et al.,Fiziol. Zh. im. I. M. Sechenova,80(7), 99–112 (1994).

    Google Scholar 

  75. 75.

    S. M. Antonov, J. W. Johnson, and N. Y. Lukomskaya,Mol. Pharmacol.,47(3), 558–567 (1995).

    PubMed  CAS  Google Scholar 

  76. 76.

    E. Acquas, J. C. Day, and H. C. Fibiger,Eur. J. Pharmacol.,260(1), 85–87 (1994).

    PubMed  CAS  Article  Google Scholar 

  77. 77.

    N. Pouli, G. Fytas, G. B. Foscolos, et al.,Ann. Pharm. Fr.,53(4), 163–169 (1995).

    PubMed  CAS  Google Scholar 

  78. 78.

    V. V. Buyanov,Farmakol. Toksikol.,50(6), 37–41 (1987).

    CAS  Google Scholar 

  79. 79.

    S. Kondo, T. Morita, and S. Hirano,J. Smooth. Muscle. Res.,29(2), 63–68 (1993).

    PubMed  CAS  Google Scholar 

  80. 80.

    E. E. Nattie, A. Li, J. Mills, et al.,Respir. Physiol,96(2–3), 189–197 (1994).

    PubMed  CAS  Article  Google Scholar 

  81. 81.

    J. W. Kebabian, D. R. Britton, M. P. DeNinno, et al.,Eur. J. Pharmacol.,229(2–3), 203–209 (1992).

    PubMed  CAS  Article  Google Scholar 

  82. 82.

    K. E. Asin and D. Wirtshafter,Eur. J. Pharmacol.,235(1), 167–168 (1993).

    PubMed  CAS  Article  Google Scholar 

  83. 83.

    R. Ranaldi and R. J. Beninger,Brain-Res.,651(1–2), 283–292 (1994).

    PubMed  CAS  Article  Google Scholar 

  84. 84.

    N. Y. Huang and R. M. Kostrzewa,Eur. J. Pharmacol.,253(1–2), 163–166 (1994).

    PubMed  CAS  Google Scholar 

  85. 85.

    S. Ofori, S. De Raad, O. Bugnon, et al.,Gen. Pharmacol.,26(1), 51–57 (1995).

    PubMed  CAS  Google Scholar 

  86. 86.

    M. Azzi, D. Gully, M. Heaulme, et al.,Eur. J. Pharmacol.,255(1–3), 167–174 (1994).

    PubMed  CAS  Article  Google Scholar 

  87. 87.

    O. Valverde, R. Maldonado, M. C. Fournie Zaluski, et al.,J. Pharmacol. Exp. Ther.,270(1), 77–88 (1994).

    PubMed  CAS  Google Scholar 

  88. 88.

    N. I. Avdyunina, N. V. Klimova, A. S. Lebedeva, et al.,Khim. -Farm. Zh.,29(2), 34–36 (1995).

    Google Scholar 

  89. 89.

    C. S. Chang and S. S. Liao,J. Steroid. Biochem.,27(1–3), 123–131 (1987).

    PubMed  CAS  Article  Google Scholar 

  90. 90.

    K. E. Gerson, E. V. Krumkalns, R. L. Brindle, et al.,J. Med. Chem., No. 6, 760 (1963).

    Article  Google Scholar 

  91. 91.

    Ts. E. Agadzhanyan, D. D. Arutyunyan, N. O. Stepanyan,Khim. -Farm. Zh.,31(1), 17–18 (1997).

    CAS  Google Scholar 

  92. 92.

    H. T. Nagasawa, Y. Yost, J. A. Elberling, et al.,Biochem. Pharmacol.,45(10), 2129–2134 (1993).

    PubMed  CAS  Article  Google Scholar 

  93. 93.

    A. J. Kennedy, A. Cline, U. M. Ney, et al.,Eur. J. Respir. Dis.,71(5), 472–478 (1987).

    PubMed  CAS  Google Scholar 

  94. 94.

    D. E. Sakas, R. M. Crowell, K. Kim, et al.,Stroke,25(1), 197–201 (1994).

    PubMed  CAS  Google Scholar 

  95. 95.

    D. E. Sakas, R. M. Crowell and N. T. Zervas,Artif. Cells. Blood. Substit. Immobil. Biotechnol.,22(1), 83–89 (1994).

    PubMed  CAS  Google Scholar 

  96. 96.

    K. D. Meisheri, S. J. Humphrey, S. A. Khan, et al.,J. Pharmacol. Exp. Ther.,266(2), 655–665 (1993).

    PubMed  CAS  Google Scholar 

  97. 97.

    C. E. Ohrnberger, S. A. Khan, and K. D. Meisheri,J. Pharmacol. Exp. Ther.,267(1), 25–30 (1993).

    PubMed  CAS  Google Scholar 

  98. 98.

    S. C. Perricone, S. J. Humphrey, L. L. Skaletzky, et al.,J. Med. Chem.,37(22), 3693–3700 (1994).

    PubMed  CAS  Article  Google Scholar 

  99. 99.

    M. P. Smith, S. J. Humphrey, and W. F. Jackson,Pharmacology,49(6), 363–375 (1994).

    PubMed  CAS  Article  Google Scholar 

  100. 100.

    K. Meisheri, M. Fosset, S. Humphrey, et al.,Mol. Pharmacol.,47(1), 155–163 (1995).

    PubMed  CAS  Google Scholar 

  101. 101.

    I. E. Kovalev, L. I. Durakova, M. I. Shmar'yan, et al.,Khim. -Farm. Zh.,11(2), 3–7 (1977).

    Google Scholar 

  102. 102.

    G. L. Arutyunyan, A. A. Chachoyan, and Ts. E. Agadzhanyan,Khim. -Farm. Zh.,30(12), 20–21 (1996).

    CAS  Google Scholar 

  103. 103.

    G. L. Arutyunyan, A. A. Chachoyan, V. A. Shkulev, et al.,Khim. -Farm. Zh.,29(3), 33–35 (1995).

    CAS  Google Scholar 

  104. 104.

    V. A. Shkulev, G. G. Adamyan, Ts. E. Agadzhanyan, et al.,Khim. -Farm. Zh.,29(3), 36–37 (1995).

    CAS  Google Scholar 

  105. 105.

    L. N. Lavrova, A. M. Vasil'ev, V. S. Korytnyi, et al.,Khim. -Farm. Zh.,27(3), 38–40 (1993).

    CAS  Google Scholar 

  106. 106.

    L. N. Lavrova, I. P. Savchanko, D. M. Vasil'ev, et al.,Khim. -Farm. Zh.,27(8), 40–43 (1993).

    CAS  Google Scholar 

  107. 107.

    A. Banerjee, C. Roman, and M. A. Heymann,Pediatr. Res.,36(4), 474–480 (1994).

    PubMed  CAS  Google Scholar 

  108. 108.

    C. E. Austin and J. C. Foreman,J. Physiol. Lond.,478(Pt 2), 351–356 (1994).

    PubMed  CAS  Google Scholar 

  109. 109.

    F. Suzuki, J. Shimada, H. Nonaka, et al.,J. Med. Chem.,35(19), 3578–3581 (1992).

    PubMed  CAS  Article  Google Scholar 

  110. 110.

    A. E. Davey and D. C. Horwell,Bioorg. Med. Chem.,1(1), 45–58 (1993).

    PubMed  CAS  Article  Google Scholar 

  111. 111.

    A. G. Blommaert, J. H. Weng, A. Dorville, et al.,J. Med. Chem.,36(20), 2868–2877 (1993).

    PubMed  CAS  Article  Google Scholar 

  112. 112.

    V. Ya. Parinov, M. D. Ktrieva, and Ya. Yu. Polis,Eksp. Klin. Farmakoterap. (Zinatne), No. 15, 60–64 (1986).

    Google Scholar 

  113. 113.

    Centers for Disease Control. Prevention and Control of Influenza: Recommendations of Immunization Practices Advisory Committee (ACIP).MMWR 41 (Suppl RR-9), 1–17 (1992).

    Google Scholar 

  114. 114.

    Anon. Influenza Prevention, 1987–1988,Med. Lett., Drugs Ther.,29, 81–82 (1987).

    Google Scholar 

  115. 115.

    Symmetrel (Amantadine Hydrochloride) Prescribing Information, Barnhart E. R., publisher.Physicians Desk Reference, 44th ed., Oradell, Medical Economics Company, 929–930 (1990).

    Google Scholar 

  116. 116.

    Yu. B. Belousov, V. S. Moiseev, and V. K. Lepakhin,Clinical Pharmacology and Pharmacotherapy [in Russian], Universum Publ., Moscow (1997), pp. 345, 493.

    Google Scholar 

  117. 117.

    V. A. Aleksandrov, K. M. Pozharisskii, A. Ya. Likhachev, et al.,Vopr. Onkol.,8(9), 23–28 (1982).

    Google Scholar 

  118. 118.

    M. C. Nahata and M. T. Brady,Eur. J. Clin. Pharmacol.,30(6), 719–722 (1986).

    PubMed  CAS  Article  Google Scholar 

  119. 119.

    E. L. Anderson, L. P. Van Voris, J. Bartram, et al.,Antimicrob. Agents Chemother.,31(7), 1140–1142 (1987).

    PubMed  CAS  Google Scholar 

  120. 120.

    L. I. Bugaeva, G. P. Dudchenko, L. S. Mazanova, et al.,Abstracts of Papers.The 2nd All-Russia Congr. “Humans and Drugs” [in Russian], Farmedinfo, Moscow (1995), p. 48.

    Google Scholar 

  121. 121.

    T. V. Khamidova, A. A. Spasov, L. I. Bugaeva, et al.,J. Physiol. Biochem. (Rev. Esp. Fisiol.),53(1), 152 (1997).

    Google Scholar 

  122. 122.

    T. V. Khamidova, A. A. Spasov, L. I. Bugaeva, et al.,Abstracts of 11th Noordwijkerhout- Camerino Symposium “Trends in Drug Research” 11–15 May, Noordwijkerhout, the Netherlands (1997a), p. 65.

  123. 123.

    I. N. Yozhitsa, A. A. Sparov, L. I. Bugaeva, et al.,J. Physiol. Biochem. (Rev. Esp. Fisiol.),53(1), 153 (1997).

    Google Scholar 

  124. 124.

    N. V. Korobov and A. N. Yavorskii,Farmakol. Toksikol.,44(3), 338–342 (1981).

    PubMed  CAS  Google Scholar 

  125. 125.

    P. J. Creaven, S. F. Zakrzewski, W. R. Greco, et al.,Cancer. Chemother. Pharmacol., No. 2, 122–128 (1988).

    Google Scholar 

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Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 34, No. 1, pp. 3–9, January, 2000.

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Spasov, A.A., Khamidova, T.V., Bugaeva, L.I. et al. Adamantane derivatives: Pharmacological and toxicological properties (review). Pharm Chem J 34, 1–7 (2000). https://doi.org/10.1007/BF02524549

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Keywords

  • NMDA Receptor
  • Memantine
  • Piperazine
  • Amantadine
  • Adamantane