Skip to main content
SpringerLink
Log in

Sentinel node mapping in lung cancer

  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Lymph node metastases are the most significant prognostic factor in localized non-small-cell lung cancer (NSCLC). Nodal micrometastases may not be detected with current standard histologic methods. We review our experience with intraoperative injection of radioisotope, the current state of the technique, and the experience of other groups with alternate methods and tracers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Bollen EC, van Duin CJ, Theunissen PH, et al. Mediastinal lymph node dissection in resected lung cancer: morbidity and accuracy of staging.Ann Thorac Surg 1993;55:961–6.

    Article  PubMed  CAS  Google Scholar 

  2. Keller SM, Adak S, Wagner H, Johnson DH. Mediastinal lymph node dissection improves survival in patients with stages II and IIIa non-small cell lung cancer. Eastern Cooperative Oncology Group.Ann Thorac Surg 2000;70:358–65.

    Article  PubMed  CAS  Google Scholar 

  3. Mountain CF, Dresler CM. Regional lymph node classification for lung cancer staging.Chest 1997;111:1718–23.

    PubMed  CAS  Google Scholar 

  4. Kubuschok B, Passlick B, Izbicki JR, et al. Disseminated tumor cells in lymph nodes as a determinant for survival in surgically resected non-small-cell lung cancer.J Clin Oncol 1999;17:19–24.

    PubMed  CAS  Google Scholar 

  5. Osaki T, Oyama T, Gu CD, et al. Prognostic impact of micrometastatic tumor cells in the lymph nodes and bone marrow of patients with completely resected stage I non-small-cell lung cancer.J Clin Oncol 2002;20:2930–6.

    Article  PubMed  Google Scholar 

  6. Liptay MJ, Masters GA, Winchester DJ, et al. Intraoperative radioisotope sentinel lymph node mapping in non-small cell lung cancer.Ann Thorac Surg 2000;70:384–9.

    Article  PubMed  CAS  Google Scholar 

  7. Tomita M, Ayabe K, Kawahara K, et al. [Esophageal stenosis following postoperative irradiation for lung cancer].Rinsho Kyobu Geka 1985;5:224–8.

    PubMed  CAS  Google Scholar 

  8. Andre F, Grunenwald D, Pignon JP, et al. Survival of patients with resected N2 non-small-cell lung cancer: evidence for a subclassi-fication and implications.J Clin Oncol 2000;18:2981–9.

    PubMed  CAS  Google Scholar 

  9. Nomori H, Horio H, Naruke T, et al. Use of technetium-99m tin colloid for sentinel lymph node identification in non-small cell lung cancer.J Thorac Cardiovasc Surg 2002;124:486–92.

    Article  PubMed  Google Scholar 

  10. Ohta Y, Oda M, Wu J, et al. Can tumor size be a guide for limited surgical intervention in patients with peripheral non-small cell lung cancer? Assessment from the point of view of nodal micrometastasis.J Thorac Cardiovasc Surg 2001;122:900–6.

    Article  PubMed  CAS  Google Scholar 

  11. Little AG, DeHoyos A, Kirgan DM, et al. Intraoperative lymphatic mapping for non-small cell lung cancer: the sentinel node technique.J Thorac Cardiovasc Surg 1999;117:220–4.

    Article  PubMed  CAS  Google Scholar 

  12. Schmidt FE, Woltering EA, Webb WR, et al. Sentinel nodal assessment in patients with carcinoma of the lung.Ann Thorac Surg 2002;74:870–4.

    Article  PubMed  Google Scholar 

  13. Sugi K, Fukuda M, Nakamura H, Kaneda Y. Comparison of three tracers for detecting sentinel lymph nodes in patients with clinical N0 lung cancer.Lung Cancer 2003;39:37–40.

    Article  PubMed  Google Scholar 

  14. Lardinois D, Brack T, Gaspert A, et al. Bronchoscopic radioisotope injection for sentinel lymph-node mapping in potentially resectable non-small-cell lung cancer.Eur J Cardiothorac Surg 2003;23: 824–7.

    Article  PubMed  CAS  Google Scholar 

  15. Liptay MJ, Grondin SC, Fry WA, et al. Intraoperative sentinel lymph node mapping in non-small-cell lung cancer improves detection of micrometastases.J Clin Oncol 2002;20:1984–8.

    Article  PubMed  Google Scholar 

  16. Sugi K, Kaneda Y, Sudoh M, et al. Effect of radioisotope sentinel node mapping in patients with cT1 N0 M0 lung cancer.J Thorac Cardiovasc Surg 2003;126:568–73.

    Article  PubMed  Google Scholar 

  17. Nakagawa T, Minamiya Y, Katayose Y, et al. A novel method for sentinel lymph node mapping using magnetite in patients with non-small cell lung cancer.J Thorac Cardiovasc Surg 2003;126: 563–7.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Thoracic Surgery, Evanston Northwestern Healthcare, Burch 100, 2650 Ridge Avenue, 60201, Evanston, IL

    Michael J. Liptay MD

Authors
  1. Michael J. Liptay MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Michael J. Liptay MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Liptay, M.J. Sentinel node mapping in lung cancer. Annals of Surgical Oncology 11 (Suppl 3), 271S–274S (2004). https://doi.org/10.1007/BF02523644

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02523644

Key Words

Search

Navigation