Abstract
The aim of the SNAC trial is to determine if sentinel node biopsy (SNB) produces less morbidity and equivalent cancer-related outcomes in comparison with immediate axillary clearance (AC) in women with early breast cancer. The intervention is SNB followed by immediate AC, or SNB followed by AC only if the SNB specimen is positive. This is a multicenter, centrally randomized phase III trial of 1000 women stratified according to age, tumor palpability, lymphatic mapping technique, and center. Accrual rate is 26 women per month; 789 women have been randomized to date. Analysis of the first 150 women indicates good compliance with study treatment and acceptable surgical technique.
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References
Carter CL, Allen C, Henson DE. Relation of tumour size, lymph nodes status and survival in 24, 740 breast cancer cases.Cancer 1989;63:181–7.
Fisher ER, Anderson S, Redmond C, et al. Pathologic findings from the National Surgical Adjuvant Breast Project Protocol B-06: 10 year pathological and clinical prognostic discriminants.Cancer 1993;71:2507–14.
Kissin MW, Querci-Della-Rovere G, Easton D, et al. Risk of lymphoedema following the treatment of breast cancer.Br J Surg 1986;73:580–4.
Aitken RJ, Gayes MN, Rodger A, et al. Arm morbidity within a trial of mastectomy and either node sample with selective radiotherapy or axillary clearance.Br J Surg 1989;76:568–71.
Giuliano AE, Kirgan DM, Guenther JM, et al. Lymphatic mapping and sentinel lymphadenectomy in breast cancer.Ann Surg 1994; 220:391–401.
Veronesi U, Paganelli G, Galimberti V, et al. Sentinel-node biopsy to avoid axillary dissection in breast cancer with clinically negative lymph nodes.Lancet 1997;349:1864–7.
Cox CE, Pendas S, Cox JM, et al. Guidelines for sentinel node biopsy and lymphatic mapping of patients with breast cancer.Ann Surg 1998;227:645–53.
Kollias J, Gill PG, Chatterton BE, et al. Reliability of sentinel node status in predicting axillary lymph node involvement in breast cancer.MJA 1999;171:461–5.
Casley-Smith JR. Measuring and representing peripheral oedema and its alterations.Lymphology 1994;27:56–70.
Aaronson NK, Ahmedzai S, Bergman B, et al. The EORTC QLQ-C30: a quality of life instrument for use in international clinical trials in oncology.J Natl Cancer Inst 1993;85:365–76.
Sprangers MAG, Groenvold M, Arraras JI, et al. The European Organization for Research and Treatment of Cancer breast cancer-specific quality-of-life questionnaire module: first results from a three-country field study.J Clin Oncol 1996;14: 2756–68.
Baxter NN. The Body Image After Breast Cancer Questionnaire: the design and testing of a disease specific measure.Dissertation Abstracts International, Section B: The Sciences & Engineering 1999;59(12-B):6258.
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Gill, P.G. Sentinel lymph node biopsy versus axillary clearance in operable breast cancer: The RACS SNAC trial, a multicenter randomized trial of the royal Australian college of surgeons (RACS) section of breast surgery, in collaboration with the national health and medical research council clinical trials center. Annals of Surgical Oncology 11 (Suppl 3), 216S–221S (2004). https://doi.org/10.1007/BF02523632
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DOI: https://doi.org/10.1007/BF02523632