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Texture analysis of technegas lung ventilation images

  • Medical Physics and Imaging
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Abstract

Technegas lung ventilation images sometimes have ‘hot spots’, particularly in patients with respiratory disease. A novel technique is presented for quantifying this ‘spottiness’ using morphological texture analysis. A set of 32 images from patients with various respiratory diseases is studied. Images are filtered at a range of scales using morphological opening, and the slopes of image metrics versus structuring element size are used as texture parameters. The results are compared with the opinions of three experienced nuclear medicine physicians who have classified the images into two groups, ‘spotty’ and ‘non-spotty’, and have ranked the former. For the spotty images, the computer and observer ranks are compared; the highest correlation is rs=0.66 (p=0.01) for a single parameter, andr s =0.71 (p<0.01) for a combination of two parameters. Using a pair of parameters, 83% and 90% correct classification rates are obtained for the spotty and non-spotty classes, respectively. It is concluded that these texture parameters provide a useful measure of image spottiness, and it is demonstrated that this technique is superior to previously published methods. The practical value of the technique is illustrated using two applications.

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References

  • Agnew, J. E. (1984): ‘Aerosol contributions to the investigation of lung structure and ventilatory functions’Clarke, S. W. andPavia, D. (Eds.): ‘Aerosols and the lung: clinical and experimental aspects’ (Butterworths, London) pp. 92–126

    Google Scholar 

  • Agnew, J. E., Bateman, J. R. M., Pavia, D., andClarke, S. W. (1984): ‘Radionuclide demonstration of ventilatory abnormalities in mild asthma,’Clin. Sci.,66, pp. 525–531

    Google Scholar 

  • Agnew, J. E., Francis, R. A., Pavia, D., andCarke, S. W. (1982): ‘Quantitative comparison of99Tcm-aerosol and81Kim ventilation images,’Clin. Phys. Physiol. Meas.,3, pp. 21–30

    Article  Google Scholar 

  • Armitage, P., andBerry, G. (1987): ‘Statistical methods in medical research’ (Blackwell Scientific Publications, Oxford, UK)

    Google Scholar 

  • Burch, W. M., Sulijvan, P. J., andMcLaren, C. J. (1986): ‘Technegas—a new ventilation agent for lung scanning,’Nucl. Med. Comm.,7, pp. 865–871

    Google Scholar 

  • Chatfield, C., andCollins, A. J. (1980): ‘Introduction to multivariate analysis’ (Chapman & Hall, London.)

    MATH  Google Scholar 

  • Cinotti, L., Edery, S., Kahn, E., Susskind, H., Brill, A. B., andDi Paola, R. (1990): ‘Lung scintigraphy clustering by texture analysis,’Eur. J. Nucl. Med.,16, pp. 353–359

    Article  Google Scholar 

  • Emmet, P. C., Love, R. G., Hannan, W. J., Millar, A. M., andSoutar, C. A. (1984): ‘The relationship between the pulmonary distribution of inhaled fine aerosols and tests of small airways function,’Bull. Eur. Physiopathol. Respir.,20, pp. 325–332

    Google Scholar 

  • Garrard, C. S., Gerrity, T. R., Schreiner, J. F., andYeates, D. B. (1981): ‘The characterisation of radioaerosol deposition in the healthy lung by histogram distribution analysis,’Chest,80, (Suppl.), pp. 840–842

    Google Scholar 

  • Haralick, R. M., Sternberg, S. R., andZhuang, X. (1987): ‘Image analysis using mathematical morphology,’IEEE Trans.,PAMI-9, pp. 532–549

    Google Scholar 

  • Hayes, M., andTaplin, G. V. (1980): ‘Lung imaging with radioaerosols for the assessment of airways disease,’Sem. Nucl. Med.,10, pp. 243–251

    Article  Google Scholar 

  • Isawa, T., Teshima, Y., Anazawa, Y., Miki, M., andMotomiya, M. (1991): ‘Technigas for inhalation lung imaging,’Nucl. Med. Comm.,12, pp. 47–55

    Google Scholar 

  • James, J. M., Herman, K. J., Lloyd, J. J., Shields, R. A., Testa, H. J., Church, S., andStretton, T. B. (1991): ‘Evaluation of 99m-Tc Technegas ventilation scintigraphy in the diagnosis of pulmonary embolism,’Br. J. Radiol.,64, pp. 711–719

    Google Scholar 

  • James, J. M., Lloyd, J. J., Leahy, B. C., Shields, R. A., Prescott, M. C., andTesta, H. J. (1992): ‘99mTc-Technegas and krypton-81 m ventilation scintigraphy: a comparison in known respiratory disease,’ ——ibid.,65, pp. 1075–1082

    Article  Google Scholar 

  • Jasiobedski, P., andTaylor, C. J. (1991): ‘Automated analysis of retinal images’ Proc. British Machine Vision Conf. 1991 (Mowforth, P. (Ed.) (Springer-Verlag, Glasgow) pp. 276–283

    Google Scholar 

  • Laube, B. L., Links, J. M., Wagner, H. N. J., Norman, P. S., Koller, D. W., Lafrance, N. D., andAdams, G. K. I. (1988): ‘Simplified assessment of fine aerosol distribution in human airways,’J. Nucl. Med.,29, pp. 1057–1065

    Google Scholar 

  • Lemb, M., Oei, T. H., Eifert, H., andGunther, B. (1993): ‘Technegas: a study of particle structure, size and distribution,’Eur. J. Nucl. Med.,20, pp. 576–579

    Article  Google Scholar 

  • Lloyd, J. J., James, J. M., Shields, R. A., Testa, H. J. (1994): ‘The influence of inhalation technique on Technegas particle deposition and image appearance in normal volunteers,’Eur. J. Nucl. Med.,21, pp. 394–398

    Article  Google Scholar 

  • Miller, P., andAstley, S. (1992): ‘Classification of breast tissue by texture analysis,’Image Vis. Comput.,10, pp. 277–282

    Article  Google Scholar 

  • Peltier, P., Bardies, M., Chetanneau, A., andChatal, J.-F. (1992): ‘Comparison of technetium-99mC and phytate aerosol in ventilation studies,’Eur. J. Nucl. Med.,19, pp. 349–354

    Google Scholar 

  • Peltier, P., De Faucal, P., Chetanneau, A., andChatal, J.-F. (1990): ‘Comparison of technetium-99m and krypton-81m in ventilation studies for the diagnosis of pulmonary embolism,’Nucl. Med. Comm.,11, pp. 631–638

    Google Scholar 

  • Santolicandro, A., Fornai, E., Marini C., Palla, A., Solfanelli, S., andGiuntini, C. (1975): ‘Uneven distribution of minimicrospheres in patients with obstructive lung disease,’J. Nucl. Biol. Med.,19, pp. 112–120

    Google Scholar 

  • Serra, J. (1982): ‘Image analysis and mathematical morphology’ (Academic Press, London.)

    MATH  Google Scholar 

  • Strong, J. C., andAgnew, J. E. (1989): ‘The particle size distribution of technegas and its influence on regional lung deposition,’Nucl. Med. Comm.,10, pp. 425–430

    Google Scholar 

  • Therrien, C. W. (1989): ‘Decision estimation and classification: an introduction to pattern recognition and related topics’ (John Wiley & Son, New York.)

    MATH  Google Scholar 

  • Werman, M., andPeleg, S. (1985): ‘Min-Max operators in texture analysis,’IEEE Trans.,PAMI-7, pp. 731–733

    Google Scholar 

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Lloyd, J.J., Taylor, C.J., James, J.M. et al. Texture analysis of technegas lung ventilation images. Med. Biol. Eng. Comput. 33, 52–57 (1995). https://doi.org/10.1007/BF02522946

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  • DOI: https://doi.org/10.1007/BF02522946

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