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Tropolone, a ligand for a lipophilic chelate with technetium-99m

  • Medical Radionuclides and the Quality of Radiopharmaceuticals
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Abstract

A lipophilic chelate formed from tropolone and99mTc is described. Radiochemical yields of the chelate were 90–95%. The radiochemical purity of neutral chelate as determined by HPLC was greater than 95%. The octanol/water partition coefficient of the chelate was 3.2 Whole-body distribution studies of the labeled chelate were carried out in rats.

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Authors and Affiliations

  1. Department of Medicinal Chemistry/Pharmacognosy and Department of Radiology, University of Maryland at Baltimore, 636 West Lombard Street, 21201, Baltimore, Maryland, (USA)

    L. A. Spitznagle, C. A. Marino & S. Kasina

Authors
  1. L. A. Spitznagle
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  2. C. A. Marino
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  3. S. Kasina
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Spitznagle, L.A., Marino, C.A. & Kasina, S. Tropolone, a ligand for a lipophilic chelate with technetium-99m. J. Radioanal. Chem. 74, 307–313 (1982). https://doi.org/10.1007/BF02520382

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  • DOI: https://doi.org/10.1007/BF02520382

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