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Automatic isotope gas analysis of tritium labelled organic materials

III. Determination of tritium in organic compounds and biological samples by a combustion method combined with isotope exchange

  • Physical Methods Section
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Abstract

An isotope analytical procedure and an automatic instrument developed for the determination of tritium in organic compounds and biological materials by internal gas counting are described. The sample is burnt in a stream of oxygen and the combustion products including water vapour carrying the tritium are led onto a column of molecular sieve-5A heated to 550 °C. Tritium is retained temporarily on the column, then transferred into a stream of hydrogen by isotope exchange. After addition of butane, the tritiated hydrogen is led into an internal detector and enclosed there for radioactivity measurement. The procedure, providing quantitative recovery, is completed in five minutes. It is free of memory effect and suitable for the determination of tritium in a wide range of organic compounds and samples of biological origin.

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Authors and Affiliations

  1. Central Research Institute for Chemistry of the Hungarian Academy of Sciences, Pusztaszeri ut 59-67, 1025, Budapest, (Hungary)

    I. Gács, S. Mlinkó, K. Payer & L. Ötvös

  2. Chinoin Factory for Pharmaceutical and Chemical Products, Budapest, (Hungary)

    Z. Vargay

  3. Research Institute for Pharmaceutical Chemistry, Budapest, (Hungary)

    D. Bánfi

  4. Patentbureau Danubia, Budapest, (Hungary)

    T. Palágyi

Authors
  1. I. Gács
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  2. S. Mlinkó
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  3. K. Payer
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  4. Z. Vargay
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  5. L. Ötvös
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  6. D. Bánfi
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  7. T. Palágyi
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Gács, I., Mlinkó, S., Payer, K. et al. Automatic isotope gas analysis of tritium labelled organic materials. J. Radioanal. Chem. 46, 109–119 (1978). https://doi.org/10.1007/BF02519734

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  • DOI: https://doi.org/10.1007/BF02519734

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