Analytical procedures for radiochemical control of water-soluble99mTc-labelled radiopharmaceuticals
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In this paper chromatographic systems for the accurate and reliable determination of the percentage of different species (free pertechnetate, particulate99mTc and labelled99mTc) in99mTc-labelled radiopharmaceuticals are described. The procedures are based on the simultaneous run of two different chromatograms, one in 85% CH3OH and the other in 15% H3PO4. Also, 0.9% NaCl can be used instead of 15% H3PO4 for the second chromatogram. Alternative procedures applying two dimensional chromatography on Whatman No. 1 paper or silica G plates with 85% CH3OH for the first run and 15% H3PO4 for the second are given. The applicability of these procedures is limited to water-soluble radiopharmaceuticals.
KeywordsPhosphoric Acid Paper Chromatography Paper Strip Methyl Ethyl Ketone Monomethyl Ether
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