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Journal of Radioanalytical Chemistry

, Volume 60, Issue 1, pp 237–245 | Cite as

Determination of trace elements in cardiotonic drugs by neutron activation analysis

  • G. D. Kanias
Physical Methods Section

Abstract

Potassium may be intimately involved to the action of cardiac glycosides. Chlorine and potassium also act as diuretics. The elements chlorine, manganese, potassium and sodium are determined by instrumental neutron activation analysis in all the cardiotonic drugs which are currently used in Greece. All the available pharmaceutical forms of these drugs were analysed (pills, injections, water solutions). It has been found that there is a wide variation among the different values for managanese, sodium and chlorine while for potassium values are relatively constant. Results are discussed from the pharmacological point of view. It is proposed to study the role of manganese in cardiotonic drugs as well as the effect of potassium addition in oral pharmaceutical form of cardiotonic drugs in decreasing the toxicity of cardiac glycosides.

Keywords

Digoxin Neutron Activation Analysis Instrumental Neutron Activation Analysis Pharmaceutical Form Cardiac Glycoside 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    L. C. BATE, M. J. PRO, Int. J. Appl. Radiation Isotopes, 15 (1964) 111.CrossRefGoogle Scholar
  2. 2.
    W. BOCK-WERTHMANN, G. PAPACOSTIDIS, A. P. GRIMANIS, J. PETROU, D. GEORGIOU, M. VASSILAKI-GRIMANI, Demo Report 74/15 Greek Atomic Energy Commission Athens, Greece, 1974.Google Scholar
  3. 3.
    W. C. BOWMAN, M. J. RAND, G. B. WEST, Textbook of Pharmacology, Blackwell Scientific Publications, Oxford and Edinbourg, 1968.Google Scholar
  4. 4.
    Documenta Geigy, Scientific Tables, 6th ed. Konrad Diem, Published by J. R. GEIGY S. A., Basel, Switzerland, 1962.Google Scholar
  5. 5.
    R. D. GIBBS, Chemotaxonomy of Flowering Plants, Vol. 1, McGill-Queen’s University Press, Montreal and London, 1974.Google Scholar
  6. 6.
    O. JOHANSEN, G. LUNDE, E. STEINNES, Institutt for Atomenergi, Kjeller Norway, Kjeller Report KR-91, 1965.Google Scholar
  7. 7.
    M. MARGOSIS, J. T. TANNER, J. P. F. LAMBERT, J. Pharm. Sci., 60 No. 10 (1971) 1550.CrossRefGoogle Scholar
  8. 8.
    R. R. PARIS, H. MOYSE, Précis de Matiére Médicale, Vol. 1, 2nd ed., Masson et Cie, Paris, 1976.Google Scholar
  9. 9.
    Proc. 1st Intern. Pharmacological Meeting, New Aspects of Cardiac Glycosides, Vol. 3, Symp. Publications Division, Pergamon Press, Oxford-London-New York-Paris, 1963.Google Scholar
  10. 10.
    L. M. REYNOLDS, W. V. KESSLER, J. E. CHRISTIAN, P. L. ZIEMER, J. Pharm. Sci., 56 No. 4 (1967) 437.CrossRefGoogle Scholar
  11. 11.
    H. L. SCHLESINGER, M. J. PRO, C. M. HOFFMAN, M. COHAN, J. Assoc. Offic. Agr. Chemists, 48 No. 6 (1965) 1139.Google Scholar
  12. 12.
    M. M. TUCKERMAN, L. C. BATE, G. W. LEDDICOTTE, J. Pharm. Sci., 53 (1964) 983.CrossRefGoogle Scholar

Copyright information

© Akadémiai Kiadó 1980

Authors and Affiliations

  • G. D. Kanias
    • 1
  1. 1.Radioanalytical Laboratory, Chemistry DepartmentNuclear Research Center “Demokritos”AthensGreece

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