Skip to main content
SpringerLink
Log in

Determination of trace elements in cardiotonic drugs by neutron activation analysis

  • Physical Methods Section
  • Published:
Journal of Radioanalytical Chemistry Aims and scope Submit manuscript

Abstract

Potassium may be intimately involved to the action of cardiac glycosides. Chlorine and potassium also act as diuretics. The elements chlorine, manganese, potassium and sodium are determined by instrumental neutron activation analysis in all the cardiotonic drugs which are currently used in Greece. All the available pharmaceutical forms of these drugs were analysed (pills, injections, water solutions). It has been found that there is a wide variation among the different values for managanese, sodium and chlorine while for potassium values are relatively constant. Results are discussed from the pharmacological point of view. It is proposed to study the role of manganese in cardiotonic drugs as well as the effect of potassium addition in oral pharmaceutical form of cardiotonic drugs in decreasing the toxicity of cardiac glycosides.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. L. C. BATE, M. J. PRO, Int. J. Appl. Radiation Isotopes, 15 (1964) 111.

    Article  CAS  Google Scholar 

  2. W. BOCK-WERTHMANN, G. PAPACOSTIDIS, A. P. GRIMANIS, J. PETROU, D. GEORGIOU, M. VASSILAKI-GRIMANI, Demo Report 74/15 Greek Atomic Energy Commission Athens, Greece, 1974.

  3. W. C. BOWMAN, M. J. RAND, G. B. WEST, Textbook of Pharmacology, Blackwell Scientific Publications, Oxford and Edinbourg, 1968.

    Google Scholar 

  4. Documenta Geigy, Scientific Tables, 6th ed. Konrad Diem, Published by J. R. GEIGY S. A., Basel, Switzerland, 1962.

  5. R. D. GIBBS, Chemotaxonomy of Flowering Plants, Vol. 1, McGill-Queen’s University Press, Montreal and London, 1974.

    Google Scholar 

  6. O. JOHANSEN, G. LUNDE, E. STEINNES, Institutt for Atomenergi, Kjeller Norway, Kjeller Report KR-91, 1965.

  7. M. MARGOSIS, J. T. TANNER, J. P. F. LAMBERT, J. Pharm. Sci., 60 No. 10 (1971) 1550.

    Article  CAS  Google Scholar 

  8. R. R. PARIS, H. MOYSE, Précis de Matiére Médicale, Vol. 1, 2nd ed., Masson et Cie, Paris, 1976.

    Google Scholar 

  9. Proc. 1st Intern. Pharmacological Meeting, New Aspects of Cardiac Glycosides, Vol. 3, Symp. Publications Division, Pergamon Press, Oxford-London-New York-Paris, 1963.

  10. L. M. REYNOLDS, W. V. KESSLER, J. E. CHRISTIAN, P. L. ZIEMER, J. Pharm. Sci., 56 No. 4 (1967) 437.

    Article  CAS  Google Scholar 

  11. H. L. SCHLESINGER, M. J. PRO, C. M. HOFFMAN, M. COHAN, J. Assoc. Offic. Agr. Chemists, 48 No. 6 (1965) 1139.

    CAS  Google Scholar 

  12. M. M. TUCKERMAN, L. C. BATE, G. W. LEDDICOTTE, J. Pharm. Sci., 53 (1964) 983.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Radioanalytical Laboratory, Chemistry Department, Nuclear Research Center “Demokritos”, Agia Paraskevi Attikis, Athens, Greece

    G. D. Kanias

Authors
  1. G. D. Kanias
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kanias, G.D. Determination of trace elements in cardiotonic drugs by neutron activation analysis. J. Radioanal. Chem. 60, 237–245 (1980). https://doi.org/10.1007/BF02518299

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02518299

Keywords

Search

Navigation