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The synthesis of13N-labelled nitrite of high specific activity and purity

  • Medical Radionuclides and the Quality of Radiopharmaceuticals
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Abstract

An improvement in a method for the synthesis of13NO −2 from13NO −3 with specific activity>30 mCi/mL and radiochemical purity>99% is described.13NO −3 is produced by the16O(p, α)13N reaction using a recirculating water target and 20 MeV protons.13NO −2 is synthesized by reduction of13NO −3 in a cadmium-copper column. Contaminating13NH +4 is removed by rotatory evaporation at pH>11.0. The synthetic procedure takes less than 20 minutes from collection of irradiated target water to sterilization of the radiopharmaceutical.

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References

  1. E. A. WALKER, L. GRICIUTE, M. CASTEGNARO, R. E. LYLE, Environmental Aspects of N-Nitroso Compounds; International Agency for Research on Cancer, Lyon, Switzerland, 1978.

    Google Scholar 

  2. M. KIESE, Methemoglobinemia: A Comprehensive Treatise; CRC Press, Cleveland, Ohio, U.S.A., 1973.

    Google Scholar 

  3. C. P. WOLK, J. THOMAS, P. W. SHAFFER, S. M. AUSTIN, A. GALONSKY, J. Biol. Chem., 251 (1976) 5027.

    CAS  Google Scholar 

  4. E. GOLDSTEIN, N. F. PEEK, N. J. PARKS, H. H. HINES, E. P. STEFFEY, B. TARKINGTON, Am. Rev. Resp. Dis., 115 (1977) 403.

    CAS  Google Scholar 

  5. J. C. MEEKS, C. P. WOLK, J. THOMAS, W. LOCKAU, P. W. SHAFFER, S. M. AUSTIN, S.-W. CHIEN, A. GALONSKY, J. Biol. Chem., 252 (1977) 7894.

    CAS  Google Scholar 

  6. M. G. STRAATMANN, Int. J. Appl. Radiat. Isotopes, 28 (1977) 13.

    Article  CAS  Google Scholar 

  7. N. J. PARKS, K. A. KROHN, Int. J. Appl. Radiat. Isotopes, 29 (1978) 754.

    Article  CAS  Google Scholar 

  8. E. D. WOOD, F. A. J. ARMSTRONG, F. A. RICHARDS, J. Mar. Biol. Assn. U.K., 47 (1967) 23.

    Article  CAS  Google Scholar 

  9. R. S. TILBURY, J. R. DAHL, Radiat. Res., 70 (1977) 646.

    Google Scholar 

  10. F. A. COTTON, G. WILKINSON, Advanced Inorganic Chemistry, Interscience Publishers, NY, U.S.A., 1972, pp. 339–366.

    Google Scholar 

  11. A. C. MAEHLY, B. CHANCE, Methods of Biochemical Analysis I; Interscience Publishers, NY, U.S.A., 1954, p. 357.

    Book  Google Scholar 

  12. S. M. AUSTIN, A. GALONSKY, J. BORTINS, C. P. WOLK, Nucl. Inst. Meth., 126 (1975) 373

    Article  CAS  Google Scholar 

  13. N. J. PARKS, N. F. PEEK, E. GOLDSTEIN, Int. J. Appl. Radiat. Isotopes, 26 (1975) 683.

    Article  CAS  Google Scholar 

  14. T. A. SKOKUT, C. P. WOLK, J. THOMAS, J. C. MEEKS, P. W. SHAFFER, Plant Physiol., 62 (1978) 299.

    Article  CAS  Google Scholar 

  15. W. A. PETTIT, R. S. TILBURY, G. A. DIGENIS, R. H. MORTARA, J. Label. Comp. Radiopharm., 13 (1977) 119.

    Article  CAS  Google Scholar 

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Author notes

  1. M. W. McElfresh

    Present address: Department of Chemistry, Washington University, 63110, St. Louis, MO, USA

Authors and Affiliations

  1. Crocker Nuclear Laboratory, University of California, 95616, Davis, CA, USA

    M. W. McElfresh

  2. Department of Bacteriology, University of california, 95616, Davis, CA, USA

    J. C. Meeks

  3. Radiobiology Laboratory, School of Veterinary Medicine, University of California, 95616, Davis, CA, USA

    N. J. Parks

Authors
  1. M. W. McElfresh
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  2. J. C. Meeks
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  3. N. J. Parks
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McElfresh, M.W., Meeks, J.C. & Parks, N.J. The synthesis of13N-labelled nitrite of high specific activity and purity. J. Radioanal. Chem. 53, 337–344 (1979). https://doi.org/10.1007/BF02517932

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  • DOI: https://doi.org/10.1007/BF02517932

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