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Decomposition rates of radiopharmaceutical indium chelates in serum

  • Medical Radionuclides and the Quality of Radiopharmaceuticals
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Abstract

The rates at which six small aminopolycarboxylate chelates of trivalent111In and three protein-bound chelates of111In deliver indium to the serum protein transferrin have been studied in sterile human serum at pH 7.3, 37°C. Sterically hindered chelates containing a substituent on an ethylene carbon of EDTA decompose with rates in the range 0.03 to 0.11% per day—one to two orders of magnitude slower than other chelates. Only small differences are observed between rates of decomposition for low-molecular-weight chelates and for protein-bound chelates having analogous structures.

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References

  1. M. W. SUNDBERG, C. F. MEARES, D. A. GOODWIN, C. I. DIAMANTI, J. Med. Chem., 17 (1974) 1304.

    Article  CAS  Google Scholar 

  2. W. C. ECKELMAN, S. M. KARESH, R. C. REBA, J. Pharm. Sci. 64 (1975) 704.

    Article  CAS  Google Scholar 

  3. M. D. LOBERG, M. COOPER, E. HARVEY, P. CALLERY W. FAITH, J. Nucl. Med., 17 (1976) 633.

    CAS  Google Scholar 

  4. P. S. CALLERY, W. C. FAITH, M. D. LOBERG, A. T. FIELDS, E. B. HARVEY, M. D. COOPER, J. Med. Chem., 19 (1976) 962.

    Article  CAS  Google Scholar 

  5. G. E. KREJCAREK, K. L. TUCKER, Biochem. Biophys. Res. Comm., 77 (1977) 581.

    Article  CAS  Google Scholar 

  6. W. C. ECKELMAN, S. M. LEVENSON, Int. J. Appl. Rad. Isotope, 28 (1977) 67.

    Article  CAS  Google Scholar 

  7. C. S-H. LEUNG, C. F. MEARES, D. A. GOODWIN, Int. J. Appl. Rad. Isotopes, 29 (1978) 687.

    Article  CAS  Google Scholar 

  8. G. W. BATES, C. BILLUPS, P. SALTMAN, J. Biol. Chem., 242 (1967) 2816.

    Google Scholar 

  9. A. E. HARMUTH-HOENE, M. VLADAR, R. OHRTMANN, Chem. Biol. Interact., 1 (1970) 271.

    Article  CAS  Google Scholar 

  10. T. B. ROGERS, R. E. FEENEY, C. F. MEARES, J. Biol. Chem., 252 (1977) 8108.

    CAS  Google Scholar 

  11. J. D. CARR, R. A. LIBBY, D. W. MARGERUM, Inorg. Chem., 6 (1967) 1083.

    Article  CAS  Google Scholar 

  12. C. F. MEARES, D. A. GOODWIN, C. S-H. LEUNG, A. Y. GIRGIS, D. J. SILVESTER, A. D. NUNN, P. J. LAVENDER, Proc. Natl. Acad. Sci. USA, 73 (1976) 3803.

    Article  CAS  Google Scholar 

  13. S. M. YEH, D. G. SHERMAN, C. F. MEARES, Anal, Biochem. (in press).

  14. C. F. MEARES, L. H. DeRIEMER, D. A. GOODWIN, in Bleomycin: Chemical, Biochemical, and Biological Aspects, S. M. HECHT (Ed.), Springer-Verlag, New York, 1979 in press.

    Google Scholar 

  15. L. H. DeRIEMER, C. F. MEARES, D. A. GOODWIN, J. Med. Chem., 22 (1979) 1019.

    Article  CAS  Google Scholar 

  16. D. A. GOODWIN, C. F. MEARES, L. H. DeRIEMER, C. I. DIAMANTI, R. L. GOOD, unpublished results.

  17. A. N. GLAZER, R. J. DELANGE, D. S. SIGMAN, Chemical Modification of Proteins, American-Elsevier, New York, 1975, p. 113.

    Google Scholar 

  18. C. S-H. LEUNG, C. F. MEARES, Biochem. Biophys. Res. Comm., 75 (1977) 149.

    Article  CAS  Google Scholar 

  19. A. WHITE, P. HANDLER, E. SMITH, Principles of Biochemistr, McGraw-Hill, san Francisco, 1973, 5th ed. p. 802 and 806.

    Google Scholar 

  20. J. D. CARR, K. TORRANCE, C. J. CRUZ, C. N. REILLY, Anal. Chem., 39 (1967) 1358.

    Article  CAS  Google Scholar 

  21. D. W. MARGERUM, G. R. CAYLEY, D. C. WEATHERBURN, G. K. PAGENKOPF, in Coordination Chemistry, Vol. 2, A. E. MARTELL (Ed.), American Chemical Society, Washington, D. C., 1978, pp. 1–220.

    Google Scholar 

  22. R. E. SHEPHERD, G. M. HODGSON, D. W. MARGERUM, Inorg. Chem., 10 (1971) 989.

    Article  Google Scholar 

  23. D. W. MARGERUM, P. J. MENARDI, D. L. JANES, Inorg. Chem., 6 (1967) 283.

    Article  CAS  Google Scholar 

  24. S. M. YEH, C. F. MEARES, Experientia, 35 (1979) 715.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Chemistry Department, University of California, 95616, Davis, California, USA

    S. M. Yeh & C. F. Meares

  2. Stanford University School of Medicine, 94304, California, USA

    D. A. Goodwin

  3. Department of Nuclear Medicine, Veterans Administration Medical Center, 94304, Palo Alto, California, USA

    D. A. Goodwin

Authors
  1. S. M. Yeh
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  2. C. F. Meares
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  3. D. A. Goodwin
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Yeh, S.M., Meares, C.F. & Goodwin, D.A. Decomposition rates of radiopharmaceutical indium chelates in serum. J. Radioanal. Chem. 53, 327–336 (1979). https://doi.org/10.1007/BF02517931

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  • DOI: https://doi.org/10.1007/BF02517931

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