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Cyclotron isotopes and radiopharmaceuticals XXXI. Improvements in77Br production and radiochemical separation from enriched78Se+

  • Medical Radionuclides and the Quality of Radiopharmaceuticals
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Abstract

An improved method for production of >100 mCi of77Br with the78Se(p, 2n)77Br nuclear reaction and a 4π water-cooled target containing encapsulated metallic78Se or a Pb78Se alloy has been developed. The77Br was separated with ∼98% radiochemical yield and a radionuclidic purity of 98.9%. The time required to isolate carrier-free77Br free of metallic impurities was less than 4hrs. Isotopically enriched78Se was quantitatively recovered.

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Authors and Affiliations

  1. Children's Hospital Medical Center, Harvard Medical School, 02115, Boston, MA, USA

    C. P. Madhusudhan & S. Treves

  2. Chemistry Department, Brookhaven National Laboratory, 11973, Upton, NY, USA

    A. P. Wolf & R. M. Lambrecht

Authors
  1. C. P. Madhusudhan
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  2. S. Treves
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  3. A. P. Wolf
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  4. R. M. Lambrecht
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Additional information

This research was partially supported by NIH Grant No. Ro1 H1 18487-01, and Performed at Brookhaven National Laboratory under contract with the U.S. Department of Energy and supported by its Division of Basic Energy Sciences.

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Madhusudhan, C.P., Treves, S., Wolf, A.P. et al. Cyclotron isotopes and radiopharmaceuticals XXXI. Improvements in77Br production and radiochemical separation from enriched78Se+ . J. Radioanal. Chem. 53, 299–305 (1979). https://doi.org/10.1007/BF02517928

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  • DOI: https://doi.org/10.1007/BF02517928

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