Abstract
Carrier-free201+202Tl have been produced in the cyclotron by (p, xn) reactions on mercury targets and used as a trcer for thallium in metallobiochemistry of heavy metal pollution. The separation of201+202Tl radioisotopes from Hg involved a solvent extraction method leading to labelled univalent Tl(I) ions. This radioactive solution was used to prepare different201+202Tl labelled compounds such as inorganic Tl(III) ions and organic dimethylthallium. Quality controls have been applied directly on the different radioactive solutions immediately before their administrations to rats in order to ensure that thallium had the chemical form expected. A summary of the main results concerning different aspects of the metabolic investigations on rats such as absorption, retention, excretion, transplacental transport and influence of the different chemical forms of thallium on its metabolism is also reported.
Similar content being viewed by others
References
H. J. BOWEN, in Trace Elements in Biochemistry, Academic Press, London, 1966.
J. C. ENGLISH, Med. J. Austr., 1 (1954) 780.
V. ZITKO, Sci. Total Environ., 4 (1975) 185.
I. C. SMITH, B. L. CARSON, in Trace Metals in the Environment, Thallium Vol. I, Ann. Arbor Science, Ann Arbor, Michigan (USA), 1977.
VON B. PRINZ, G. H. M. KRAUSE, U. STRATMANN, Staub Reinhalt. Luft, 39 (1979) 457.
E. SABBIONI, L. GOETZ, E. MARAFANTE, C. GREGOTTI, L. MANZO, Sci. Total Environ., 15 (1980) 123.
E. SABBIONI, F. GIRARDI, Sci. Total Environ., 7 (1977) 145.
E. ACERBI, C. BIRATTARI, M. CASTIGLIONI, F. RESMINI, J. Radioanal. Chem. 34 (1976) 191.
C. F. WILLIAMSON, J. P. BOUJOUT, J. PICARD, Rep. CEA-R 3042, 1966.
C. BIRATTARI, M. BONARDI, C. DE MARTINIS, F. RESMINI, A. SALOMONE, 17th European Progress Meeting, Karlsruhe, FRG, 1980.
D. BASILE, C. BIRATTARI, M. BONARDI, L. GOETZ, E. SABBIONI, A. SALOMONE, Int. J. Appl. Rad. Isotopes, 32 (1981) 403.
D. COMAR, C. CROUZEL, Radiochem. Radioanal. Letters, 23 (1975) 131.
J. D. GILE, W. M. GARRISON, J. G. HAMILTON, J. Chem. Phys., 19 (1951) 1427.
H. GILMAN, R. G. JONES, J. Am. Chem. Soc., 72 (1950) 1760.
E. B. SANDELL,in Colorimetric Determination of Traces of Metals, 2nd ed., Interscience Publishers, Inc., New York 1950, p. 560.
L. KULBERG, Mikrochemie, 19 (1936) 183.
E. SABBIONI, E. MARAFANTE, L. GOETZ, C. BIRATTARI, Radiochem. Radioanal. Letters, 31 (1977) 39.
E. SABBIONI, L. MANZO, in Progress of Neurotoxicology, L. MANZO, N. LERY, Y. LACASSE, L. ROCHE (Eds), Pergamon Press, Oxford, 1980 p. 249.
E. SABBIONI, E. MARAFANTE, J. RADE, C. GREGOTTI, A. DI NUCCI, L. MANZO in Toxicity and Hazard Evaluation, M. MERCIER, R. LAWVERYS, M. ROBERFROID (Eds), Elsevier/North Holland Biomed. Press, Amsterdam, 1980, p. 559.
E. SABBIONI, E. MARAFANTE, J. RADE, F. BERTE, R. RICHELMI, L. MANZO, Toxicol. Letters, special issue N. 1, Second Int. Congress on Toxicology, 6–11 July 1980 Brussels (Belgium), Abs., p. 155.
E. SABBIONI, L. MANZO, Factors affecting the metabolism and toxicity of thallium, Int. Congress of Neurotoxicology 27–30 September 1979, Varese, Italy, Abs. 30, p. 62.
J. E. GIBSON, B. A. BAKER, Toxicol. Appl. Pharmacol, 16 (1970) 120.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Goetz, L., Sabbioni, E., Marafante, E. et al. Biochemical studies of current environmental levels of trace elements: Cyclotron production of radiothallium and its use for metabolic investigations on laboratory animals. J. Radioanal. Chem. 67, 183–192 (1981). https://doi.org/10.1007/BF02516240
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02516240