, Volume 32, Issue 1, pp 29–33 | Cite as

Effect of intracerebral implantation of the embryonicLocus Coeruleus on the conditioned reflex avoidance reaction in rats with experimental atrophy of the frontotemporal brain cortex

  • D. A. Bevzyuk
  • T. M. Vorob’yova
  • O. G. Berchenko


We studied the effect of intracerebral grafting of the embryoniclocus coeruleus from donor rats on the conditioned reflex emotional avoidance reaction (EAR) and contents of adrenaline and noradrenaline in the brain structures and body tissues of recipient rats. Group 1 of the animals consisted of intact rats, group 2 included rats with electrolytic impairment and subsequent atrophy of the frontotemporal brain cortex regions, while in group 3 the rats with impaired cortex were subjected to parallel transplantation of the embryoniclocus coeruleus into the injured region. Group-3 animals manifested a considerable level of recovery of the conditioned reflex behavioral stereotype disturbed after the cortical injury. Biochemical analysis showed that transplantation of the embryoniclocus coeruleus exerts a rehabilitative/regulating influence on the functioning of the catecholaminergic systems in the group-3 rats.

Key words

neurotransplantation conditioned reflex avoidance reaction locus coeruleus frontotemporal cortex noradrenaline 


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Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • D. A. Bevzyuk
    • 1
  • T. M. Vorob’yova
    • 1
  • O. G. Berchenko
    • 1
  1. 1.Ukrainian Institute of Clinical and Experimental Neurology and PsychiatryMinistry of Public Health of UkraineKhar’kovUkraine

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