Advertisement

Neurophysiology

, Volume 32, Issue 1, pp 29–33 | Cite as

Effect of intracerebral implantation of the embryonicLocus Coeruleus on the conditioned reflex avoidance reaction in rats with experimental atrophy of the frontotemporal brain cortex

  • D. A. Bevzyuk
  • T. M. Vorob’yova
  • O. G. Berchenko
Article
  • 16 Downloads

Abstract

We studied the effect of intracerebral grafting of the embryoniclocus coeruleus from donor rats on the conditioned reflex emotional avoidance reaction (EAR) and contents of adrenaline and noradrenaline in the brain structures and body tissues of recipient rats. Group 1 of the animals consisted of intact rats, group 2 included rats with electrolytic impairment and subsequent atrophy of the frontotemporal brain cortex regions, while in group 3 the rats with impaired cortex were subjected to parallel transplantation of the embryoniclocus coeruleus into the injured region. Group-3 animals manifested a considerable level of recovery of the conditioned reflex behavioral stereotype disturbed after the cortical injury. Biochemical analysis showed that transplantation of the embryoniclocus coeruleus exerts a rehabilitative/regulating influence on the functioning of the catecholaminergic systems in the group-3 rats.

Key words

neurotransplantation conditioned reflex avoidance reaction locus coeruleus frontotemporal cortex noradrenaline 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    P. K. Anokhin,Biology and Neurophysiology of a Conditioned Reflex [in Russian], Meditsina, Moscow (1966).Google Scholar
  2. 2.
    Summaries of Reports from the All-Union Symposium “Neurochemical Mechanisms of Memory Control” [in Russian], Pushchino (1984).Google Scholar
  3. 3.
    T. M. Vorob’yova, “On the state of emotional tension under conditions of transformation of a conditioned-reflex stereotype and influence of unconditioned reward,” in:Proceedings of the XXIII All-Union Conference on the Problems of Higher Nervous Activity [in Russian], Gor’kii (1972), pp. 62–63.Google Scholar
  4. 4.
    D. O. Bevzyuk, “Effect of distant transplantation of the embryoniclocus coeruleus in rats with modeled atrophy of the frontotemporal brain cortex,”Fiziol. Zh.,44, No. 3, 81 (1998).Google Scholar
  5. 5.
    I. P. Bystron’ and V. A. Ottelin, “Structural basis of correction of disturbed brain functions by transplantation of dissociated embryonic brain tissue,”Sechenov Fiziol. Zh.,81, No. 4, 91–94 (1995).Google Scholar
  6. 6.
    T. M. Vorob’yova, O. G. Berchenko, V. V. Geiko, et al.,A Technique for Treating CNS Disorders, Russian patent No. 96122455 awarded November 29, 1995.Google Scholar
  7. 7.
    T. M. Vorob’yeva, O. G. Berchenko, and V. V. Geiko, “A technique for transplantation of specific embryonic tissue into a recipient brain and its efficiency,”Ukr. Visn. Psykhonevrol.,3, No. 2(6), 246–248 (1995).Google Scholar
  8. 8.
    L. V. Polezhayev, M. A. Aleksandrova, V. N. Vitvitskii, and L. V. Cherkasova,Transplantation of Brain Tissue in Biology and Medicine [in Russian], Meditsina, Moscow (1993).Google Scholar
  9. 9.
    V. P. Podachin, “Compensation of behavioral disorders with a technique of transplantation of the embryonic nerve tissue,” in:Brain and Behavior [in Russian], Nauka, Moscow (1990), pp. 532–541.Google Scholar
  10. 10.
    L. V. Polezhayev and M. A. Aleksandrova,Transplantation of Brain Tissue in the Norm and Pathology [in Russian], Nauka, Moscow (1986).Google Scholar
  11. 11.
    Bengion, M. Kokaia, P. Brundin, and O. Lindwall, “Seizure suppression in kindling epilepsy by intrahippocampuslocus coeruleus grafts: evidence for an alpha-2 adrenoreceptor-mediated mechanism,”Exp. Brain. Res.,81, No. 2, 433–437 (1990).Google Scholar
  12. 12.
    B. D. Olle, J. Kikwadre, P. Brundin, et al., “Intracerebral grafting of fetal noradrenergiclocus coeruleus neurons: evidence for seizure suppression,” in:Transplant. into Mammal. CNS, Amsterdam (1988), pp. 79–86.Google Scholar
  13. 13.
    H. Pribram, “On the theory of physiological psychology,”Vopr. Psykhol., No. 2, 133–156 (1961).Google Scholar
  14. 14.
    H. Pribram, “A neurophysiological approach to the analysis of the neurobehavioral deficit that follows frontal lesions,” in:Proceedings of the XVIII International Congress, Symposium 5 ‘The Frontal Lobes and Control of Behavior’ [in Russian], Nauka, Moscow (1966), pp. 9–24.Google Scholar
  15. 15.
    M. Baru, “A study of catecholamines in the urine of humans,”Biokhimiya,27, No. 2, 260–265 (1962).Google Scholar
  16. 16.
    M. Baru and T. P. Boiko, “A technique for studying catecholamines with increased specificity of a trioxyindole procedure,” in:Topical Problems of Experimental and Clinical Endocrinology [in Russian], Khar’kov (1979), pp. 126–127.Google Scholar

Copyright information

© Kluwer Academic/Plenum Publishers 2000

Authors and Affiliations

  • D. A. Bevzyuk
    • 1
  • T. M. Vorob’yova
    • 1
  • O. G. Berchenko
    • 1
  1. 1.Ukrainian Institute of Clinical and Experimental Neurology and PsychiatryMinistry of Public Health of UkraineKhar’kovUkraine

Personalised recommendations