Abstract
In acute experiments on cats we studied the modulating influence of an NO donor, nitroglycerin (NG), and a blocker of NO synthase nitro-L-arginine, methyl esther (L-NAME), on the neuronal responses in the anterior hypothalamus evoked by stimulation of evolutionary heterogeneous cortical zones. Intracerebroventricular injections of NG and L-NAME relatively rarely resulted in fundamental changes in the types of cortically evoked responses (8.8%; 65 cases among 736 testings). Yet, 72% of the L-NAME injections evoked significant increases in the frequency of the neuronal background activity, while 64% of NG injections resulted in suppression of the background activit. Possible mechanisms of modifications of the synaptic efficiency in cortico-hypothalamic projections determined by shifts in the NO concentration are discussed.
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References
S. Moncada, R. M. J. Palmer, and E. A. Higgs, “Biosynthesis of nitric oxide from L-arginine. A pathway for regulation of cell function and communication,”Biochem. Pharmacol.,38, 1709–1715 (1989).
R. J. Knowles, M. Palacios, R. M. J. Palmer, and S. Moncada, “Nitric oxide in the brain” in:Nitric Oxide from L-arginine, a Bioregulatory System, S. Moncada and E. A. Higgs (eds.), Excerpta Medica, Amsterdam, New York, Oxford (1990), pp. 139–147.
H. Liu, M. L. Terrell, V. Bui, et al., “Nitric oxide control of drinking, vasopressin and oxytocin release and blood pressure in dehydrated rats,”Physiol. Behav.,63, No. 5, 763–769 (1998).
S. L. Baader and K. Schilling, “Glutamate receptors mediate dynamic regulation of nitric oxide synthase expression in cerebellar granule cells,”J. Neurosci.,16, No. 4, 1440–1449 (1996).
S. R. Vincent and H. Kimura, “Histochemical mapping of nitric oxide synthase in the rat brain,”Neuroscience,46, No. 4, 755–784 (1992).
P. Kara and M. J. Friedlander, “Dynamic modulation of cerebral cortex synaptic function by nitric oxide,”Prog. Brain Res.,118, 118–198 (1998).
V. N. Kazakov, P. Ya. Kravtsov, I. E. Kuznetsov, and A. V. Tereschenko, “Influences from different areas of the cerebral cortex on preoptic neurons: morphological and electrophysiological data,”Neuroscience,51, No. 4, 961–972 (1992).
L. V. Natrus, P. Ya. Kravtsov, and I. E. Kuznetsov, “Corticofugal effects on the neurons of different regions of the hypothalamus,”Neurofiziologiya/Neurophysiology,29, No. 3, 167–175 (1997).
P. Ya. Kravtsov and L. V. Natrus, “Peculiarities of the responses of hypothalamic neurons to application of serial cortical stimuli,”Arkh. Klin. Éksp. Med.,7, No. 1, 83–87 (1998).
F. Reinoso-Suarez,Topographischer Hirnatlas der Katze, H. von E. Merk, Darmstadt (1961).
L. N. Shapoval, V. F. Sagach, L. S. Pobegailo, and L. P. Doloman, “Nitric oxide and sympathetic-activating cardiovascular neurons of the ventrolateral medullary region in cats,”Neirofiziologiya/Neurophysiology,28, Nos. 2/3, 111–120 (1996).
A. I. Fisyunov, O. A. Kryshtal, and A. Ya. Tsyndrenko, “Potentiation of voltage-dependent calcium chanel currents by NMDA receptor agonists,”Neurophysiology/Neiropfiziologiya 29, No. 1, 14–20 (1997).
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Kuznetsov, I.É., Gaidarova, O.V., Natrus, L.V. et al. Influence of NO on the background activity and corticofugal responses of anterior hypothalamus neurons. Neurophysiology 31, 345–348 (1999). https://doi.org/10.1007/BF02515118
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DOI: https://doi.org/10.1007/BF02515118