Modeling of mechanisms and dynamics of pharmacological effects of psychotropic drugs in view of temporal organization of neuronal processes
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Non-equilibrium kinetic models of ligand-receptor interaction are considered to describe the types and quantitative peculiarities of pharmacological effects of exogenous modulators, agonists, and antagonists of central neurotransmitter systems. Using the proposed model, we analyze synaptic ligand-receptor non-equilibrium (impulse) interactions against the background of steady-state interaction of a given ligand with postsynaptic receptors. The type of pharmacological effects of exogenous ligands is shown to be determined by temporal organization of specific synaptic processes (namely, the relation between the rates of receptor conformational transitions and elimination of the transmitter).
KeywordsPharmacological Effect Psychotropic Drug Synaptic Cleft Conformational Transition Temporal Organization
- 1.H. J. Tallarida and L. S. Jacob,The Dose-Response Relation in Pharmacology, S. n., New York (1979).Google Scholar
- 2.I. V. Komissarov,Mechanisms of Chemical Sensivity of Synaptic Membranes [in Russian], Naukova Dumka, Kyiv (1986).Google Scholar
- 3.M. M. Kats and É. F. Lavretskaya, “Receptors of brain biogenic amines: structure, functional mechanisms, and interactions with physiologically active drugs”,Iogi Nauki Tekh. VINITI Akad. Nauk SSSR, Ser. Bioorg. Khim.,8, 228 (1986).Google Scholar
- 5.I. V. Komissarov and I. I. Abramets,Modulation of Efficiency of Interneuronal Connections by Bioregulators and Pharmacological Agents [in Russian], Naukova Dumka, Kyiv (1994).Google Scholar