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Modeling of mechanisms and dynamics of pharmacological effects of psychotropic drugs in view of temporal organization of neuronal processes

  • Proceedings of the Ist (Constituent) Conference of the Ukrainian Neuroscience Society (Kyiv, November 24–26, 1998)
  • Poster Communications
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Neurophysiology Aims and scope

Abstract

Non-equilibrium kinetic models of ligand-receptor interaction are considered to describe the types and quantitative peculiarities of pharmacological effects of exogenous modulators, agonists, and antagonists of central neurotransmitter systems. Using the proposed model, we analyze synaptic ligand-receptor non-equilibrium (impulse) interactions against the background of steady-state interaction of a given ligand with postsynaptic receptors. The type of pharmacological effects of exogenous ligands is shown to be determined by temporal organization of specific synaptic processes (namely, the relation between the rates of receptor conformational transitions and elimination of the transmitter).

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Authors and Affiliations

  1. Mechnikov State University, Odessa, Ukraine

    N. Ya. Golovenko, V. G. Zin’kovskii, O. V. Zhuk & M. S. Zhuk

Authors
  1. N. Ya. Golovenko
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  2. V. G. Zin’kovskii
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  3. O. V. Zhuk
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  4. M. S. Zhuk
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Golovenko, N.Y., Zin’kovskii, V.G., Zhuk, O.V. et al. Modeling of mechanisms and dynamics of pharmacological effects of psychotropic drugs in view of temporal organization of neuronal processes. Neurophysiology 31, 285–286 (1999). https://doi.org/10.1007/BF02515106

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  • DOI: https://doi.org/10.1007/BF02515106

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