Modeling of mechanisms and dynamics of pharmacological effects of psychotropic drugs in view of temporal organization of neuronal processes
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Non-equilibrium kinetic models of ligand-receptor interaction are considered to describe the types and quantitative peculiarities of pharmacological effects of exogenous modulators, agonists, and antagonists of central neurotransmitter systems. Using the proposed model, we analyze synaptic ligand-receptor non-equilibrium (impulse) interactions against the background of steady-state interaction of a given ligand with postsynaptic receptors. The type of pharmacological effects of exogenous ligands is shown to be determined by temporal organization of specific synaptic processes (namely, the relation between the rates of receptor conformational transitions and elimination of the transmitter).
KeywordsPharmacological Effect Psychotropic Drug Synaptic Cleft Conformational Transition Temporal Organization
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