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Neurophysiology

, Volume 31, Issue 4, pp 285–286 | Cite as

Modeling of mechanisms and dynamics of pharmacological effects of psychotropic drugs in view of temporal organization of neuronal processes

  • N. Ya. Golovenko
  • V. G. Zin’kovskii
  • O. V. Zhuk
  • M. S. Zhuk
Proceedings of the Ist (Constituent) Conference of the Ukrainian Neuroscience Society (Kyiv, November 24–26, 1998) Poster Communications
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Abstract

Non-equilibrium kinetic models of ligand-receptor interaction are considered to describe the types and quantitative peculiarities of pharmacological effects of exogenous modulators, agonists, and antagonists of central neurotransmitter systems. Using the proposed model, we analyze synaptic ligand-receptor non-equilibrium (impulse) interactions against the background of steady-state interaction of a given ligand with postsynaptic receptors. The type of pharmacological effects of exogenous ligands is shown to be determined by temporal organization of specific synaptic processes (namely, the relation between the rates of receptor conformational transitions and elimination of the transmitter).

Keywords

Pharmacological Effect Psychotropic Drug Synaptic Cleft Conformational Transition Temporal Organization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Kluwer Academic/Plenum Publishers 1999

Authors and Affiliations

  • N. Ya. Golovenko
    • 1
  • V. G. Zin’kovskii
    • 1
  • O. V. Zhuk
    • 1
  • M. S. Zhuk
    • 1
  1. 1.Mechnikov State UniversityOdessaUkraine

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