Postnatal dynamics of the heparin-binding activity of rat cerebellar cells
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The heparin-binding activity was measured in different extracts from the cerebellum within an initial period of the postnatal development (the 1st–30th postnatal days) of rats, aiming at investigating molecular organization of the intercellular matrix. According to the results of the hard-phase carbohydrate-enzyme analysis, the highest heparin-binding activity is typical of the extracellular (urea) fraction of cerebellar proteins of newborn rats. The level of the activity markedly dropped by the 15th day of postnatal development of the rats and remained constant in older animals. The data obtained confirm the hypothesis on the regulatory role of heparin at early stages of the nerve cell morphogenesis.
KeywordsPostnatal Development Neural Cell Adhesion Molecule Heparin Binding Cerebellar Tissue External Granular Layer