Journal of Anesthesia

, Volume 8, Issue 2, pp 219–220 | Cite as

Halothane enhances the negative chronotropic and dromotropic effects of calcium channel antagonists

  • Masanobu Manabe
  • Iwao Ookawa
  • Takashi Matsukawa
  • Teruo Kumazawa
  • Yukiko Kataoka
  • Eri Takimoto
  • Wasa Ueda
Clinical Reports
  • 22 Downloads

Key words

Halothane Calcium channel antagonist Cardiac interaction Inhalation anesthetics 

References

  1. 1.
    Manabe M, Motomura S, Hashimoto K (1988) Interaction between diltiazem and halothane or enflurane in the canine blood-perfused papillary muscle and sinoatrial node preparations cross-circulated by chronically instrumented conscious donor dog. J Anesth 2:50–62PubMedCrossRefGoogle Scholar
  2. 2.
    Chelly JE, Hysing ES, Abernethy DR, et al. (1986) Effects of inhalational anesthetics on verapamil pharmacokinetics in dogs. Anesthesiology 65:266–271PubMedGoogle Scholar
  3. 3.
    Hantler CB, Wilton N, Learned DM, et al. (1987) Impaired myocardial conduction in patients receiving diltiazem therapy during enflurane anesthesia. Anesthesiology 67:94–96PubMedCrossRefGoogle Scholar
  4. 4.
    Tosone SR, Reves JG, Kissin I, et al. (1983) Hemodynamic responses to nifedipine in dogs anesthetized with halothane. Anesth Analg 62:903–908PubMedCrossRefGoogle Scholar

Copyright information

© JSA 1994

Authors and Affiliations

  • Masanobu Manabe
    • 1
  • Iwao Ookawa
    • 1
  • Takashi Matsukawa
    • 2
  • Teruo Kumazawa
    • 2
  • Yukiko Kataoka
    • 1
  • Eri Takimoto
    • 1
  • Wasa Ueda
    • 1
  1. 1.Department of Anesthesiology and ResuscitologyKochi Medical SchoolKochiJapan
  2. 2.Department of AnesthesiologyYamanashi Medical CollegeYamanashiJapan

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