Journal of Anesthesia

, Volume 8, Issue 3, pp 293–296 | Cite as

The effect of pH adjustment of 1% lidocaine on the onset of sensory and motor blockade of epidural anesthesia in nonpregnant gynecological patients

  • Taeko Fukuda
  • Hiroshi Naito
Original Articles


Using a double-blind randominzed study protocol, we examined the distribution of sensory blockade and the quality of motor blockade after epidural anesthesia with 1% lidocaine with or without bicarbonate in nonpregnant gynecological patients.

Alkalinization significantly decreased the time to onset of sensory blockade. However, there were no statistically significant differences between the low-pH and high-pH groups with respect to motor blockade or the distribution of sensory blockade.

We conclude that pH-adjusted 1% lidocaine offers the advantage of a more rapid onset of sensory blockade, while motor blockade and the distribution of anesthesia are unaffected by pH change in epidural anesthesia.

Key words

Local anesthetic Lidocaine pH-adjustment Epidural anesthesia Nonpregnant gynecological patients 


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Copyright information

© JSA 1994

Authors and Affiliations

  • Taeko Fukuda
    • 1
  • Hiroshi Naito
    • 1
  1. 1.Department of Anesthesiology, Institute of Clinical MedicineUniversity of TsukubaTsukuba-cityJapan

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