Journal of Anesthesia

, Volume 8, Issue 3, pp 253–255 | Cite as

RETRACTED ARTICLE: Airway occlusion pressure is an indicator of respiratory depression with isoflurane

  • Yoshitaka Fujii
  • Hiroyoshi Tanaka
  • Hidenori Toyooka
  • Keisuke Amaha
Original Articles


The purpose of this study was to elucidate the respiratory depressant effects of isoflurane (0%–1.0%) using airway occlusion pressure (P0.1), a known index of the output of the respiratory centers, in ten anesthetized patients. P0.1 was measured as the pressure change obtained after the first 0.1 sec of spontaneous inspiration against the occluded airway. A significant decrease in minute volume (\(\dot V_E \)) and a significant increase in PaCO 2 were not observed during the periods of isoflurane 1.0% at the end-tidal concentration compared with those of control period (0% isoflurane) (P<0.05), whereas a significant decrease in P0.1 was observed during the period of isoflurane 0.5%. Our results suggested that P0.1 was a more sensitive indicator of respiratory depression than PaCO 2 or\(\dot V_E \), and the respiratory center was depressed with a considerably lower concentration (0.5%) of isoflurane.

Key words

Airway occlusion pressure (P0.1Isoflurane 


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Copyright information

© JSA 1994

Authors and Affiliations

  • Yoshitaka Fujii
    • 1
  • Hiroyoshi Tanaka
    • 1
  • Hidenori Toyooka
    • 2
  • Keisuke Amaha
    • 2
  1. 1.Department of AnesthesiologyToride Kyodo General HospitalToride City, IbarakiJapan
  2. 2.Department of Anesthesiology and Critical Care MedicineTokyo Medical and Dental University School of MedicineTokyoJapan

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