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Electrocatalytic glucose sensor

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Abstract

An electrocatalytic glucose sensor for in vivo application has been developed. The sensor is a flow-through cell with three electrodes and can be integrated into a blood vessel. The principle of measurement is based on the direct electrochemical oxidation of glucose at a membrane-covered noble-metal electrode. To test the potential long-term in vivo function of the sensor, it was implanted in the carotid artery of a sheep. Thus, the sensor performance was verified over a period of 71 days. During this time, a nearly constant blood flow through the cell was achieved, which indicates good blood compatibility of the materials used. It was possible to set up a calibration that was valid over 24 days (mean error 2.3 mmol l−1). The tested cross-sensitivity of the sensor towards cysteine, acetyl salicylic acid and other small molecules shows tolerable effects on this type of glucose measurement. Only high concentrations of lactate and ethanol require a special adaptation of the calibration to suppress their influence. Minor crossensitivity and promising long-term stability recommend this type of sensor for in vivo monitoring of blood sugar level. However, for intravasal application, it is necessary to modify the present sensor design to a catheter-type construction.

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References

  • Alibis, A. M., Leibel, B. S., Ewart, T. G., Davidovac, Z., Botz, C. K. andZingg, W. (1974): ‘An artificial endocrine pancreas,’Diabetes,23, (5), pp. 389–396

    Google Scholar 

  • Armour, J. C., Lucisano, J. Y., McKean, B. D., andGough, D. A. (1990): ‘Application of chronic intravascular blood glucose sensor in dogs’,ibid.,39, (12), p. 1519–1526

    Google Scholar 

  • Bolzan, A. E., Iwasita, T., andVielstich, W. (1987): ‘On the electrochemical oxidation of glucose,’J. Electrochem. Soc.,134, (12), pp. 3052–3058

    Article  Google Scholar 

  • Drake, R. F., Messinger, S., Matsuda, S., Masse, N., O’Connel, J. Arzoumanidis, G., Colton, C. K., andBorsanyi, A. S. (1972): ‘Implantable fuel cell for an artificial heart.’ Medical Devices Applications Program, NH & LI, Bethesda, Maryland, Final Report, PB 210662

  • Fischer, U., Schenk, W., Salzsieder, E., Albrecht, G., Abel, P., andFreyse, E.-J. (1987): ‘Does physiological blood glucose control required an adaptive control strategy?,’IEEE Trans.,BME-34, (8), pp. 575–582

    Google Scholar 

  • Franetzki, M., Prestele, K., andKresse, H. (1981): ‘State of development of programme-controlled insulin dosing devices,’Electromedica,1, pp 41–48

    Google Scholar 

  • Franetzki, M. (1984): ‘Drug delivery by program or sensor control-led infusion devices,’Pharmaceut. Res., (6), pp. 237–282

    Article  Google Scholar 

  • Gebhardt, U., Luft, G., Richter, J. G., von Sturm, F. (1978): ‘Development of an implantable electrocatalytic glucose sensor’,Bioelectrochem. Bioenerg.,5, pp. 607–624

    Article  Google Scholar 

  • Gebhardt, U., Luft, G., Richter, J. G., andvon Sturm, F. (1977): ‘Entwick lung eines implantierbaren elektrokatalytischen Glucosesensors,’Biomedizin. Tèchnik,11, (22), pp. 399–400

    Article  Google Scholar 

  • Gebhardt, U., Luft, G., Mund, K., Preidel, W., andRichter, G. J. (1983): ‘Electrocatalytic glucose sensor,’Siemens Forsch.-und Entwickl.-Ber.,12, (2), pp. 91–95

    Google Scholar 

  • Giner, J., andHolleck, G. (1972): ‘Design consideration for an implantable fuel cell to power an artificial heart’in Sandstede, G. (Ed.): Electrocatalysis of fuel cells,’ (University of Washington Press, Seattle) p. 283

    Google Scholar 

  • Heitbaum, E., andHamann, C. H. (1979): ‘The electrooxidation of glucose in phosphate buffer solutions,”J. Electroanal. Chem.,100, pp. 173–183

    Article  Google Scholar 

  • Lemke, K., andLustermann, R. (1991): ‘Electrocatalytic glucose sensor for subcutaneous application,’Bioelectrochem. Bioenerg.,321, pp. 43–61

    Article  Google Scholar 

  • Lerner, H., Giner, J., Soeldner, S., andColton, C. K. (1979): ‘Electrochemical glucose oxidation on a platinized platinum electrode in Krebs-Ringer solution II,’J. Electrochem. Soc.,126, (1), pp. 237–242

    Article  Google Scholar 

  • von Lucadou, I., Luft, G., Preidel, W., andRichter, G.J. (1987): ‘The electrocatalytic glucose sensor,’Hormone Metabolic Res. Suppl. Ser.,20, Int. Symposium Reisenburg, pp. 41–43

    Google Scholar 

  • Marincic, L., Soeldner, S., Colton, C. K., Giner, J., andMorris, S. (1979): ‘Electrochemical glucose oxidation on a platinized platinum electrode in Krebs-Ringer solution I,’J. Electrochem. Soc.,126, (1), pp. 43–49

    Article  Google Scholar 

  • Pfeiffer, E. F., Thum, C., andClemens, A. H. (1974): ‘The artificial beta cell—a continuous control of blood sugar by external regulation of insulin infusion,’Horm. Metab. Res.,487, pp. 339–342

    Google Scholar 

  • Pfeiffer, E. F., andKerner, W. (1985): ‘Use of artificial pancreas and portable insulin infusion pumps in diabetes therapy: past, present and fugure,’Artif. Org.,9, pp. 129–137

    Article  Google Scholar 

  • Pfeidel, W., Luft, G., andMund, K. (1986): ‘Electrochemical sensors for biomedical applications,’Electrochem. Soc. Proc.,86–14, pp. 26–34

    Google Scholar 

  • Preidel, W., andSaeger, S. (1989): ‘In vitro measurements with electrocatalytic glucose sensor in blood,’Biomed. Biochim. Acta,48, (11/12), pp. 897–903

    Google Scholar 

  • Preidel, W., andMund, K. (1990): ‘Method for determining the concentration of electro-chemically convertible substances.’ United States Patent 4, 919, 770, 24. 4.

  • Preidel, W., Saeger, S., von Lucadou, I., andLager, W. (1991): ‘An electrocatalytic glucose sensor for in-vivo application,’Biomed. Instr. Tech.,25, (3), pp. 215–219

    Google Scholar 

  • Rao, J. R., Richter, G., von Sturm, F., andWeidlich, E. (1972): ‘Metal oxygen and glucose oxygen cells as power sources for implantable devices,’ Third Int. Conf. on Medical Physics including Medical Engineering, Chalmers University of Technology, Götenborg, Sweden,30.7

  • Rao, J. R., Richter, G., von Sturm, F., andWeidlich, E. (1973): ‘Biobrennstoffzellen als Stromquellen für implantierte elektronische Geräte,’Berichte der Bunsengesellschaft für physikalische Chemie,77 (10/11), pp. 787–790

    Google Scholar 

  • Rao, J. R., Richter, G. J., Luft, G., andvon Sturm, F. (1978): ‘Electrochemical behaviour of amino acids and their influence on the anodic oxidation of glucose in neutral media,’Biomater. Med. Devices Artif. Organs,6, (2), pp. 127–149

    Google Scholar 

  • Richter, G. J., Luft, G., andGebhardt, U. (1982): ‘Development and present status of an electrocatalytic glucose sensor,’Diabetes Care,5, (3), pp. 224–228

    Google Scholar 

  • Saeger, S. (1990): ‘Untersuchungen zur Funktionsfähigkeit des elektrokatalytischen Glucosesensors unter in-vitro-und in-vivo-Bedingungen,’ Dissertation, Universität Erlange, Germany

    Google Scholar 

  • Saeger, S., Preidel, W., von Lucadou, I., Ruprecht, L., andLager W. (1991): ‘Influence of urea on the glucose measurement by electrocatalytic sensor in the extracorporeal blood circulation of a sheep,’Biomed. Biochim. Acta,50, (7), pp. 885–891

    Google Scholar 

  • Santiago, J., Clemens, A., Clarke, W. L., andKipnis, D. (1978): ‘Closed-loop and open-loop devices for blood glucose control in normal and diabetic subjects,’Diabetes,28, (1), pp. 71–81

    Google Scholar 

  • Tegeder, V. (1991): ‘Oberflächen prozesse an der Platinelektrode bei der Glucose-Elektrooxidation.’ Dissertation, Universität Ulm, Germany

    Google Scholar 

  • Velho, G., Moatti, D., andReach, G. (1990): ‘Interference of ascorbate and acetaminophen onin vitro andin vivo glucose sensing by an implantable sensor,’ 9th Workshop of AIDSPIT Study Group, Igls Austria

  • Yao, S. J., Michuda, M., Markley, F., andWolfson, S. K. Jr. (1972): ‘A bioauto fuel cell for pacemaker power’,in Sandstede, D. (Ed.): ‘Electrocatalysis to fuel cells’ (University of Washington Press, Seattle) p. 291

    Google Scholar 

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Authors and Affiliations

  1. Corporate Research and Development, Siemens AG, Erlangen, Germany

    W. Lager, I. v. Lucadou & W. Preidel

  2. GSF-Forschungszentrum für Umwelt und Gesudheit, Munich, Germany

    L. Ruprecht

  3. Physiology & Biocybernetics Institute, University of Erlangen, Germany

    S. Saeger

Authors
  1. W. Lager
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  2. I. v. Lucadou
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  3. W. Preidel
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  4. L. Ruprecht
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  5. S. Saeger
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Lager, W., Lucadou, I.v., Preidel, W. et al. Electrocatalytic glucose sensor. Med. Biol. Eng. Comput. 32, 247–252 (1994). https://doi.org/10.1007/BF02512518

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  • DOI: https://doi.org/10.1007/BF02512518

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