Ultrafiltrate sampling device for continuous monitoring

  • D. Moscone
  • K. Venema
  • J. Korf
Physiological Measurement

Abstract

A light, portable sampling device for the continuous collection and storage of subcutaneous fluid is described. It consists of a hollow-fibre probe for ultrafiltration, a long tube for sample storage and a vacuum tube as driving force. Introduction of a restriction in the flow path allows a constant pulse-free flow as low as 100 nl min−1. The contents of the storage tube reflect the metabolic events that have happened during the 24 h collection period. The ultrafiltrate fluid collected from the subcutaneous tissue is free from large molecules and can be continuously analysed. An application in combination with a bionsensor for the analysis of glucose is described, but the device also allows monitoring of other subcutaneous constituents such as ions, metabolites, drugs and their metabolites.

Keywords

Biosensor Glucose Ultrafiltration 24 h monitoring 

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Copyright information

© IFMBE 1996

Authors and Affiliations

  • D. Moscone
    • 1
    • 2
  • K. Venema
    • 1
  • J. Korf
    • 1
  1. 1.Department of Biological PsychiatryUniversity of GroningenGroningenThe Netherlands
  2. 2.Dipartimento di Scienze e Technologie ChimicheUniversita' Tor VergataRomaItaly

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