The effects of brisk walking on markers of bone and calcium metabolism in postmenopausal women
- 85 Downloads
Weight-bearing exercise has been shown to maintain or increase bone mass in younger as well as older individuals but the mechanisms by which mechanical loading affects bone metabolism are not known in detail. Twelve postmenopausal women participated in a single bout of brisk walking (50% of VO2 max) for 90 minuttes. Calciotropic hormones and markers of type I collagen formation (PICP) and degradation (ICTP) were measured before the exercise, and 1, 24, and 72 hours following the exercise. Total body bone mineral content (BMC) and density (BMD) were measured by dual energy X-ray absorptiometry (DXA). Brisk walking did not induce any significant changes in the concentrations of ionized calcium, parathyroid hormone (PTH), calcitonin, or osteocalcin. A significant increase of PICP was noted 24 and 72 hours (P<0.01) after exertion and a significant decrease in the concentration of serum ICTP at 1 hour (P<0.05) was followed by an increase at 72 hours (P<0.001). There was no significant difference between the increases in the concentrations of PICP and ICTP at 72 hours. Strong inverse correlations between the basal levels of PTH and BMD (r=−0.78;P<0.01) as well as between osteocalcin and BMD (r=−0.83;P<0.01) were noticed. The changes in serum levels of bone collagen markers indicate an altered bone collagen turnover due to this moderate endurance exercise. The results also support the fact that serum levels of PTH as well as those of osteocalcin are associated with total body BMD in postmenopausal women.
Key wordsPhysical exercise Bone metabolism Collagen markers Parathyroid hormone Calcium
Unable to display preview. Download preview PDF.
- 6.Woo S, Knei S, Amiel D (1981) The effect of prolonged physical training on the properties of long bone: a study of Wolff's law. J Bone Joint Surg 63A:780–787Google Scholar
- 8.Rubin C, Lanyon LJ (1984) Regulation of bone formation by applied dynamic load. J Bone Joint Surg 66A:397–402Google Scholar
- 13.Mellko J, Niemi S, Risteli L, Risteli J (1994) Radioimmunoassay of the carboxyterminal propeptide of human type I procollagen. Clin Chem 36:1328–1332Google Scholar
- 20.Fellman N (1992) Hormonal and plasma volume alterations following endurance exercise. A brief review. Sports Med 13:37–49Google Scholar
- 22.Christiansen C (1993) Skeletal osteoporosis. J Bone Miner Res 8(suppl 2):S475–480Google Scholar
- 23.Avioli LV (1993) Hormonal alterations and osteoporotic syndromes. J Bone Miner Res 8(suppl 2):S511–514Google Scholar
- 24.Harms HM, Neubauer O, Kayser C, Wüstermann PR, Horn R, Brosa U, Schlinke E, Külpman W-R, von zur Mühlen A, Hesch R-D (1994) Pulse amplitude and frequency modulation of parathyroid hormone in early postmenopausal women before and on hormone replacement therapy. J Clin Endocrinol Metab 78:48–52PubMedCrossRefGoogle Scholar
- 26.Ljunghall S, Joborn H, Roxin LE, Rastad J, Wide L, Åkerstrøm G (1986) Prolonged low-intensity exercise raises the serum parathyroid hormone levels. Clin Endocrinol 25:535–542Google Scholar
- 27.Salvesen H, Piehl-Aulin K, Ljunghall S (1994) Change in levels of the carboxyterminal propeptide of type I procollagen, the carboxyterminal cross-linked telopeptide of type I collagen and osteocalcin in response to exercise in well-trained men and women. Scand J Med Sci Sports 4:186–190CrossRefGoogle Scholar
- 28.Virtanen P, Viitasalo JT, Vouri J, Väänänen K, Takala TES (1993) Effect of concentric exercise on serum muscle and collagen markers. J Appl Physiol 3:1272–1277Google Scholar