Retention and enantioselectivity properties of β-cyclodextrin polymers and derivatives on porous silica for reverse-phase liquid chromatographic separation of enantiomers
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Chiral stationary phases (CSP) based on porous silica coated with β-cyclodextrin polymer and methylated or acetylated derivatives have been prepared. Their enantiomer separation capability was tested and compared under reversed-phase mode elution conditions. Noticeable changes in retention properties werenoted and in many cases a reverse enantioselectivity was evidenced, as a consequence of a strong modification of the energy, geometry and number of points of contact between solutes and stationary phase sites of molecular recognition.
Key WordsColumn liquid chromatography Chiral stationary phase β-Cyclodextrin polymer and methylated and acetylated derivatives Enantioselectivity
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