Chromatographia

, Volume 45, Issue 1, pp 383–389 | Cite as

Retention and enantioselectivity properties of β-cyclodextrin polymers and derivatives on porous silica for reverse-phase liquid chromatographic separation of enantiomers

  • B. Sébille
  • M. Guillaume
  • C. Vidal-Madjar
  • N. Thuaud
Originals

Summary

Chiral stationary phases (CSP) based on porous silica coated with β-cyclodextrin polymer and methylated or acetylated derivatives have been prepared. Their enantiomer separation capability was tested and compared under reversed-phase mode elution conditions. Noticeable changes in retention properties werenoted and in many cases a reverse enantioselectivity was evidenced, as a consequence of a strong modification of the energy, geometry and number of points of contact between solutes and stationary phase sites of molecular recognition.

Key Words

Column liquid chromatography Chiral stationary phase β-Cyclodextrin polymer and methylated and acetylated derivatives Enantioselectivity 

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Copyright information

© Friedr. Vieweg & Sohn Verlagsgesellschaft mbH 1997

Authors and Affiliations

  • B. Sébille
    • 1
  • M. Guillaume
    • 1
  • C. Vidal-Madjar
    • 1
  • N. Thuaud
    • 1
  1. 1.Laboratoire de Physico-Chimie des Biopolymères, Unité Mixte CNRSUniversité de Paris XII n0 27ThiaisFrance

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