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Involvement of the AP-1 site within the 5′-flanking region of the stromelysin-1 gene in induction of the gene expression by UVA irradiation

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References

  1. Smith JG, Davidson EA, Sams WM, Clark RD (1962) Alterations in human dermal connective tissue with age and chronic sun damage. J Invest Dermatol 39:347–350

    Article  PubMed  CAS  Google Scholar 

  2. Uitto J (1986) Connective tissue biochemistry of the aging dermis. Age-related alterations in collagen and elastin. Dermatol Clin 4:433–446

    PubMed  CAS  Google Scholar 

  3. Sams WM, Smith JG (1961) The histochemistry of chronically sun-damaged skin. J Invest Dermatol 37:447–452

    PubMed  CAS  Google Scholar 

  4. Lever WF, Schaumburg-Lever G (1990) Histopathology of the skin, 7th edn. JB Lippincott, Philadelphia, pp 298–300

    Google Scholar 

  5. Woessner JFJ (1990) Matrix metalloproteinases and their inhibitors in connective tissue remodeling. FASEB J 5:2145–2154

    Google Scholar 

  6. Okada Y, Nagase H, Harris EDJ (1986) A metalloproteinase from human rheumatoid synovial fibroblasts that digests connective tissue matrix components. J Biol Chem 261:14245–14255

    PubMed  CAS  Google Scholar 

  7. Sawamura D, Sugawara T, Hashimoto I, Tuderman L-B, Fujimoto D, Okada Y, Utsumi N, Shikata H (1991) Increased gene expression of matrix metalloproteinase-3 (stromelysin) in skin fibroblasts from patients with severe recessive dystrophic epidermolysis bullosa. Biochem Biophys Res Commun 174: 1003–1008

    Article  PubMed  CAS  Google Scholar 

  8. Umemori EN, Bair MJ, Bauer EA, Amento EP (1991) Stromelysin expression regulates collagenase activation in human fibroblasts: dissociable control of two metalloproteinases by interferon-γ. J Biol Chem 266:23477–23482

    Google Scholar 

  9. Mauviel A (1993) Cytokine regulation of metalloproteinase gene expression. J Cell Biochem 53:822–831

    Article  Google Scholar 

  10. Chin JR, Murphy G, Werb Z (1985) Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substrates. J Biol Chem 260:12367–12376

    PubMed  CAS  Google Scholar 

  11. Matrisian LM, Bowden GT, Krieg P, Eurstenberger G, Briand JP, LeRoy P, Breathnach R (1986) The mRNA coding for the secreted protease transin is expressed more abundantly in malignant than in benign tumors. Proc Natl Acad Sci USA 83: 9413–9417

    Article  PubMed  CAS  Google Scholar 

  12. Frisch SM, Ruley HE (1987) Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasone. J Biol Chem 262:16300–16304

    PubMed  CAS  Google Scholar 

  13. Machida CM, Muldoon LL, Rodland KD, Magun BE (1988) Transcriptional modulation of transin gene expression by epidermal growth factor and transforming growth factor β. Mol Cell Biol 8:2479–2483

    PubMed  CAS  Google Scholar 

  14. Herrmann G, Wlaschek M, Lange TM, Prenzel K, Goerz G, Scharffetter-Kochanek K (1993) UVA irradiation stimulates the synthesis of various matrix-metalloproteinases (MMPs) in cultured human fibroblasts. Exp Dermatol 2:92–97

    Article  PubMed  CAS  Google Scholar 

  15. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156–159

    Article  PubMed  CAS  Google Scholar 

  16. Borden P, Song K, Heller RA (1994) The human stromelysin promoter contains a previously unreported 1.0-kb sequence. Gene 151:315–320

    Article  PubMed  CAS  Google Scholar 

  17. Sawamura D, Sato T, Kon A, Harada K, Nomura K, Hashimoto I, Tamai K, Uitto J (1994) Mouse 230-kDa bullous pemphigoid antigen gene: structural and functional characterization of the 5′-flanking region and interspecies conservation of the deduced amino-terminal peptide sequence of the protein. J Invest Dermatol 103:651–655

    Article  PubMed  CAS  Google Scholar 

  18. Schreiber E, Matthias P, Mueller MM, Schaffner W (1989) Rapid detection of octamer binding proteins with ‘mini-extracts’, prepared from a small number of cells. Nucleic Acids Res 17:6419

    PubMed  CAS  Google Scholar 

  19. Tamai K, Li K, Uitto J (1994) A novel DNA binding protein (KTP-1) recognizes a keratinocyte-specific regulatory element in the 230-kDa bullous pemphigoid antigen (BPAG1) gene. J Biol Chem 269:493–502

    PubMed  CAS  Google Scholar 

  20. Petersen MJ, Hansen C, Craig S (1992) Ultraviolet A irradiation stimulates collagenase production in cultured human fibroblasts. J Invest Dermatol 9:440–444

    Article  Google Scholar 

  21. Scharffetter K, Wlaschek M, Hogg A, Bolsen K, Schothorst A, Goerz G, Krieg T, Plewig G (1991) UVA irradiation induces collagenase in human dermal fibroblasts in vitro and in vivo. Arch Dermatol Res 283:506–511

    Article  PubMed  CAS  Google Scholar 

  22. Wlaschek M, Bolsen K, Herrmann G, Schwarz A, Wilmroth F, Heinrich PC, Goerz G, Scharffetter-Kochanek K (1993) UVA-induced autocrine stimulation of fibroblast-derived-collagenase by IL-6: a possible mechanism in dermal photodamage? J Invest Dermatol 101:164–168

    Article  PubMed  CAS  Google Scholar 

  23. Sirum-Connolly K, Brinckerhoff CE (1991) Interleukin-1 or phorbol induction of the stromelysin promoter requires an element that cooperates with AP-1. Nucleic Acids Res 19:335–341

    PubMed  CAS  Google Scholar 

  24. Nicholson RC, Mader S, Nagpal S, Leid M, Rochette-Egly C, Chambon P (1990) Negative regulation of the rat stromelysin gene promoter by retinoic acids is mediated by an AP1 binding site. EMBO J 9:4443–4454

    PubMed  CAS  Google Scholar 

  25. Stein B, Rahmsdorf HJ, Steffen A, Litfin M, Herrlich P (1989) UV-induced DNA damage is an intermediate step in UV-induced expression of human immunodeficiency virus type 1, collagenase, c-fos, and metallothionein. Mol Cell Biol 9: 5169–5181

    PubMed  CAS  Google Scholar 

  26. Wasylyk C, Gutman A, Nicholson R, Wasylyk B (1991) The c-Ets oncoprotein activates the stromelysin promoter through the same elements as several non-nuclear oncoproteins. EMBO J 10:1127–1134

    PubMed  CAS  Google Scholar 

  27. Buttice G, Kurkinen M (1993) A polyomavirus enhancer A-binding protein-3 site and Ets-2 protein have a major role in the 12-0-tetradecanoylphorbol-13-acetate response of the human stromelysin gene. J Biol Chem 268:7196–7204

    PubMed  CAS  Google Scholar 

  28. Sanz L, Berra E, Municio MM, Dominguez I, Lozano J, Johansen T, Moscat J, Diaz-Meco MT (1994) Zeta PC plays a critical role during stromelysin promoter activation by platelet-derived growth factor through a novel palindromic element. J Biol Chem 269:10044–10049

    PubMed  CAS  Google Scholar 

  29. Rutberg SE, Yang YM, Ronai Z (1992) Functional role of the ultraviolet light responsive element (UKE; TGACAACA) in the transcription and replication of polyoma DNA. Nucleic Acids Res 20:4035–4010

    Google Scholar 

  30. Devary Y, Gottlieb RA, Smeal T, Karin M (1992) The mammalian ultraviolet response is triggered by activation of Src tyrosine kinase. Cell 71:1081–1091

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Dermatology, Hirosaki University School of Medicine, 5 Zaifu-cho, 036, Hirosaki, Japan

    Daisuke Sawamura, Toshiaki Ohta, Katsumi Hanada, Hiroyasu Ishikawa, Katsuto Tamai, Harumi Yazima, Xianmin Meng, Kazuo Nomura & Isao Hashimoto

  2. Department of Dermatology, Jefferson Medical College, Philadelphia, PA, USA

    Alain Mauviel

  3. Department of Biochemistry and Molecular Biology, Jefferson Medical College, Philadelphia, PA, USA

    Jouni Uitto

Authors
  1. Daisuke Sawamura
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  2. Toshiaki Ohta
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  3. Katsumi Hanada
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  4. Hiroyasu Ishikawa
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  5. Katsuto Tamai
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  6. Harumi Yazima
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  7. Xianmin Meng
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  8. Kazuo Nomura
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  9. Isao Hashimoto
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  10. Alain Mauviel
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  11. Jouni Uitto
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Sawamura, D., Ohta, T., Hanada, K. et al. Involvement of the AP-1 site within the 5′-flanking region of the stromelysin-1 gene in induction of the gene expression by UVA irradiation. Arch Dermatol Res 288, 628–632 (1996). https://doi.org/10.1007/BF02505268

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  • DOI: https://doi.org/10.1007/BF02505268

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