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Reduced proliferative responses of peripheral blood mononuclear cells specifically toCandida albicans antigen in patients with atopic dermatitis — comparison with their normal reactivity to bacterial superantigens

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Abstract

Although reduced cutaneous reactivities toCandida, albicans have been reported in patients with atopic dermatitis (AD), there is still controversy as to whether the in vivo lymphocyte proliferation response is normal or reduced. We have also reported that patients with AD manifest a decreased cutaneous response only toC. albicans antigen in scarification patch tests. The purpose of this study was to examine whether patients with AD show normal lymphocyte transformation responses toC. albicans antigen. Peripheral blood leucocytes (PBL) from 21 patients with AD and 14 healthy control (HC) subjects were cocultured with optimal concentrations ofC. albicans antigen and of superantigens (staphylococcal enterotoxin A and B). PBL from the patients with AD showed a significantly lower response toC. albicans antigen, but there was no statistically significant difference, in PBL responses to superantigens between the patients with AD and the HC subjects. This decreased proliferative response of PBL was particularly noticeable in those whose RAST scores forC. albicans antigen were high. These results suggest the development of a specific anergy toC. albicans antigen in patients with AD.

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Authors and Affiliations

  1. Department of Dermatology, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-77, Sendai, Japan

    Misako Tanaka, Setsuya Aiba, Kazuhiro Takahashi & Hachiro Tagami

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  1. Misako Tanaka
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  2. Setsuya Aiba
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  3. Kazuhiro Takahashi
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  4. Hachiro Tagami
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Tanaka, M., Aiba, S., Takahashi, K. et al. Reduced proliferative responses of peripheral blood mononuclear cells specifically toCandida albicans antigen in patients with atopic dermatitis — comparison with their normal reactivity to bacterial superantigens. Arch Dermatol Res 288, 495–499 (1996). https://doi.org/10.1007/BF02505243

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  • DOI: https://doi.org/10.1007/BF02505243

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