Synthesis and alkylation ofN-methylmorpholinium 6-amino-3,5-dicyano-4-methylpyridine-2-thiolate
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The condensation of acetaldehyde with a twofold excess of cyanothioacetamide andN-methylmorpholine givesN-methylmorpholinium 6-amino-3,5-dicyano-4-methylpyridine-2-thiolate. This compound is also formed by recyclization of 2,6-diamino-3,5-dicyano-4-methyl-4H-thiopyran. From this pyridinethiolate, several substituted 2-alkylthiopyridines and 3,6-diamino-5-cyano-4-methyl-2-methoxycarbonylthieno[2,3-b]pyridine were obtained.
Key wordsacetaldehyde cyanothioacetamide N-methylmorpholine pyridine thiopyran condensation recyclization
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