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Reaction of different functional zones in mouse thymus and spleen lymphoid tissue to γ-irradiation

  • Morphology and Pathomorphology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

It is shown that immune organs respond to single γ-radiation of 6.9 Gy in a cyclic manner. Acute reaction characterized by spontaneous lymphocyte lysis in the thymus and spleen develops on day 1 postirradiation and takes 3 and 7 days, respectively. This is followed by enhancement of thymocyte mitotic activity and migration of young cells to the thymic cortex and splenic lymphoid tissue. Twenty-one day postirradiation lymphoid cell populations in the thymus and spleen recover to 70–90 and 55–70%, respectively.

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Authors and Affiliations

  1. Laboratory of Functional Anatomy, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow

    M. P. Sapin, L. M. Erofeeva, D. E. Grigorenko & B. S. Fedorenko

Authors
  1. M. P. Sapin
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  2. L. M. Erofeeva
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  3. D. E. Grigorenko
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  4. B. S. Fedorenko
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 4, pp. 381–384, April, 1998

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Sapin, M.P., Erofeeva, L.M., Grigorenko, D.E. et al. Reaction of different functional zones in mouse thymus and spleen lymphoid tissue to γ-irradiation. Bull Exp Biol Med 125, 416–419 (1998). https://doi.org/10.1007/BF02499175

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  • DOI: https://doi.org/10.1007/BF02499175

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