Abstract
Effect of specific immunotherapy on the expression of activation markers, apoptosis marker CD95, and peripheral blood lymphocyte morphology were studied in patients with atopic bronchial asthma. Specific therapy activated T and B cells and triggered lymphocyte apoptosis. Apoptosis may play an important role in induction of allergen tolerance during specific therapy.
Similar content being viewed by others
References
A. D. Ado,Special Allergology [in Russian], Moscow (1976).
L. Jeger,Clinical Immunology and Allergology [in Russian], vol. 1, Moscow (1990).
G. V. Poryadin, Zh. M. Salmasi, and A. I. Makarkov,Molecular mechanisms of IgE-mediated allergy [in Russian], Moscow (1996).
L. N. Fontalin,Molecular Cellular Mechanisms of Immunological Tolerance [in Russian], Moscow (1994).
G. Frimel',Immunological Methods [in Russian], Moscow (1987).
N. Itoh, S. Yonehara, A. Ishii,et al., Cell,66, 233–243 (1991).
W. Kersten,Allergol. Immunopathol., No. 12, 499–505 (1985).
T. Stalder, S. Hahn, and P. Erb,J. Immunol.,152, No. 3, 1127–1133 (1994).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 4, pp. 434–436, April, 1998
Rights and permissions
About this article
Cite this article
Poryadin, G.V., Salmasi, Z.M. & Makarkov, A.I. Lymphocyte apoptosis: Mechanism of specific immunotherapy of atopic diseases. Bull Exp Biol Med 125, 384–386 (1998). https://doi.org/10.1007/BF02499165
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02499165