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Three-component condensation in the synthesis of 4-(2-chlorophenyl)-3-cyano-5-ethoxycarbonyl-6-propyl-3,4-dihydropyridine-2(1H)-thione

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Abstract

Condensation of 2-chlorobenzaldehyde with cyanothioacetamide and ethyl butyroylacetate results in 4-(2-chlorophenyl)-3-cyano-5-ethoxycarbonyl-6-propyl-3,4-dihydropyridine-2(1H)-thione, whose further transformation affords the corresponding substituted 2-methylthio-1,4-dihydropyridine.

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References

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Authors and Affiliations

  1. Taras Shevchenko Lugansk State Pedagogical University, 2 ul. Oboronnaya, 348011, Lugansk, Ukraine

    S. G. Krivokolysko & V. D. Dyachenko

  2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 117913, Moscow, Russian Federation

    V. P. Litvinov

Authors
  1. S. G. Krivokolysko
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  2. V. D. Dyachenko
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  3. V. P. Litvinov
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Translated fromIzvestiya Akademii Nauk. Seriya Khimicheskaya, No. 1, pp. 173–175, January, 2000.

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Krivokolysko, S.G., Dyachenko, V.D. & Litvinov, V.P. Three-component condensation in the synthesis of 4-(2-chlorophenyl)-3-cyano-5-ethoxycarbonyl-6-propyl-3,4-dihydropyridine-2(1H)-thione. Russ Chem Bull 49, 176–178 (2000). https://doi.org/10.1007/BF02499088

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  • DOI: https://doi.org/10.1007/BF02499088

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