Archives of orthopaedic and traumatic surgery

, Volume 102, Issue 2, pp 128–130 | Cite as

Radiation induced osteosarcoma of the sacrum following radiation of an undiagnosed bone lesion

  • Rene Scheiden
  • Wolfgang Oberthaler
Current Problem Case

Summary

Years ago a 20-year-old patient presented with low back pain. Radiologically a cystic lesion of the sacrum was found and interpreted as malignant tumor. Without biopsy and histological diagnosis the patient was given radiation therapy with 21000 rad. One year later a similar lesion was radiated in the left femoral neck. A pathological fracture ensued recessitating several operations. Twenty years after initial radiation therapy the patient developed a rapidly growing tumor of the sacrum, metastasizing to the lungs. One year later he died.

Keywords

Osteosarcoma Giant Cell Tumor Radiation Induce Tumor Benign Bone Lesion Postradiation Sarcoma 

Zusammenfassung

Bei einem wegen Kreuzschmerzen untersuchten 20jährigem Patienten wurde vor Jahren eine röntgenologisch cystische Läsion des Kreuzbeins als malignes Neoplasma gedeutet. Ohne Probeexcision erfolgte eine Röntgenbestrahlungsserie von insgesamt 21000 rad. Ein Jahr später führte eine ebenfalls bestrahlte vermeintliche Metastase am linken Schenkelhals zu einer pathologischen Fraktur und mehrfachen Operationen. Nach 20jähriger Latenzzeit entstand ein massives Tumorwachstum im Sacrum mit Lungenmetastasen, das ein Jahr später zum Exitus führte.

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References

  1. 1.
    Brady LW (1979) Radiation-induced sarcomas of bone. Skelet Radiolog 4:72–78CrossRefGoogle Scholar
  2. 2.
    Cahan WG, Woodard HQ, Higinbotham NL, Stewart FW, Coley BL (1948) Sarcoma arising in irradiated bone; report of 11 cases. Cancer 1:3–29CrossRefPubMedGoogle Scholar
  3. 3.
    Dahlin DC: Bone tumors, 3rd ed. Charles C. Thomas, SpringfieldGoogle Scholar
  4. 4.
    Pliess G (1974) In: Doerr W (ed) Organ pathology, vol III. Thieme, StuttgartGoogle Scholar
  5. 5.
    Gowing FC (1980) Tumor histopathology. Wolfe, LondonGoogle Scholar
  6. 6.
    Jaffe HL (1958) Tumors and tumorlike conditions of the bone and joints. Lea and Febiger, PhiladelphiaGoogle Scholar
  7. 7.
    Krebs H, Baca J (1978) Riesenzelltumoren des Sacrum. Arch Orthop Trauma Surg 92:237–241PubMedCrossRefGoogle Scholar
  8. 8.
    Larsson SE, Lorentzon R, Boquist L (1975) Giant cell tumors of the spine and sacrum causing neurological symptoms. Clin Orthop 111:201–211PubMedGoogle Scholar
  9. 9.
    Lichtenstein L (1965) Bone tumors, 5th ed. Mosby, St. LouisGoogle Scholar
  10. 10.
    Lichtenstein L (1975) Deseases of bone and joints, 2nd ed. Mosby, St. LouisGoogle Scholar
  11. 11.
    Sanerkin HG (1980) Definitions of osteosarcoma, chondrosarcoma and fibrosarcoma of bone, Cancer46:178–185PubMedCrossRefGoogle Scholar
  12. 12.
    Schajowicz F (1981) Tumors and tumorlike lesions of bone and joints. Springer, Berlin Heidelberg New YorkGoogle Scholar
  13. 13.
    Sim FH, Cupps RE, Dahlin DC, Jvins JC (1972) Postradiation sarcoma of bone. J Bone Jt Surg 54-A:1479–1489Google Scholar
  14. 14.
    Spjut HJ, Dorfmann HD, Fechner RE, Ackerman L (1971) Tumors of bone and cartilage. In: Atlas of tumor pathology. Series two, Fasc 5 Washington, Armed Forces Inst of PathGoogle Scholar
  15. 15.
    Steiner GC (1965) Postradiation sarcoma of bone. Cancer 18:603PubMedCrossRefGoogle Scholar
  16. 16.
    Thurner J (1970) Iatrogene Pathologie. Urban and Schwarzenberg, MünchenGoogle Scholar

Copyright information

© Springer-Verlag 1983

Authors and Affiliations

  • Rene Scheiden
    • 1
  • Wolfgang Oberthaler
    • 2
  1. 1.Department of PathologyLandeskrankenhausFeldkirchAustria
  2. 2.Department of Orthopedic SurgeryLandeskrankenhausFeldkirchAustria

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