Abstract
Effect of cortexin, epithalamine, and human cortical and pineal peptides on the growth of sensory neurons and the development of cortex and subcortical structures is studied in organotypic culture of chick embryo brain (embryonic days 10–11). In doses of 2–200 ng/ml these preparations exhibit stimulating effect on spinal ganglia, which is seen on day 3 in culture. Cortexin (100 ng/ml) and brain peptide (20 ng/ml) stimulate growth of cultured brain cortex explants. Epithalamine (200 ng/ml) and pineal peptide (100 ng/ml) stimulate the development of subcortical structures in culture. These peptides can be used as stimulators of neurite regeneration.
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 3, pp. 332–336, March, 1998
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Khavinson, V.K., Chalisova, N.I. & Okulov, V.B. Natural and synthetic cytomedines in nerve tissue culture. Bull Exp Biol Med 125, 294–297 (1998). https://doi.org/10.1007/BF02496886
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DOI: https://doi.org/10.1007/BF02496886