Abstract
Clinical significance of intermolecular relationships of bone matrix collagen pyridinoline and deoxypyridinoline in the urine is assessed in 137 cancer patients with metastases to the bones and 16 without metastatic involvement of the bone. Bone tissue resorption markers were studied by solid-phase extraction and high performance liquid chromatography and excretion was expressed as the ratio to urine creatinine. The levels of collagen pyridine bonds were significantly higher in cancer patients with metastases to bones than in patients without metastases and in control group consisting of 137 normal subjects. In addition, urine levels of pyridinoline and deoxypyridinoline in cancer patients without metastases to bones were significantly higher than in controls. A significant increase in urinary excretion of pyridine bonds was observed in bone involvement in patients with malignant tumors of different localization: breast, lungs, and prostate. The data indicate a possibility of using collagen pyridine bonds for early detection of metastatic destruction of the skeleton.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
J. J. Body and P. D. Delmas,J. Clin. Endocrinol. Metab.,74, No. 3, 471–475 (1992).
B. F. Boyce and H. Chen, in:Metastatic Bone Disease: Fundamental and Clinical Aspects, Berlin-Heidelberg (1994), pp. 46–58.
R. E. Coleman, S. Houston, I. James,et al. Brit. J. Cancer,65, 766–768 (1992).
P. D. Delmas,Acta Orthop. Scand.,66, 176–182 (1995).
P. D. Delmas, A. Schlemmer, E. Gineyts,et al., J. Bone Miner. Res.,6, 639–644 (1991).
H. Fleish,Biphosphonates in Bone Disease, New York-London (1995).
F. Li, P. I. Pitt, R. Sherwood,et al., Eur. J. Clin. Invest.,23, 566–571 (1993).
A. Lipton, L. Demers, Y. Daniloff,et al., Clin. Chem.,39, 614–618 (1993).
K. K. Miyamoto, S. A. McSherry, S. P. Robins,et al., J. Urol.,151, 909–913 (1994).
C. R. Paterson, S. P. Robins, J. M. Horobin,et al., Brit. J. Cancer,64, 884–886 (1991).
D. A. Pratt, Y. Daniloff, A. Duncan, and S. P. Robins,Anal. Biochem.,207, 168–175 (1992).
C. P. Price and P. W. Thompson,Ann. Clin. Biochem.,32, 244–260 (1995).
S. P. Robins,Clin. Rheumatol.,2, 1–36 (1996).
S. P. Robins,Acta Orthop. Scand.,66, 171–175 (1995).
S. P. Robins, D. Black, C. R. Paterson,et al., Eur. J. Clin. Invest.,21, 310–315 (1991).
M. Sano, K. Kushida, M. Takahashi,et al., Brit. J. Cancer,70, 701–703 (1994).
A. Schlemmer, C. Hassager, B. J. Pedersen, and C. Christiansen,J. Bone Miner. Res.,9, 1883–1888 (1994).
M. J. Seibel, I. Lambrinoudaki, and A. Zipf, in:Metastatic Bone Disease: Fundamental and Clinical Aspects, Berlin-Heidelberg (1994), pp. 109–126.
S. -I. Takeuchi, K. Arai, H. Saitoh,et al., J. Urol.,156 1691–1695 (1996).
W. Withold, W. Friedrich, and H. Reinauer,Ann. Clin. Biochem.,33, 421–427 (1996).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 3, pp. 323–328, March, 1998
Rights and permissions
About this article
Cite this article
Lyubimova, N.V., Kushlinskii, N.E. & Robins, S.P. Bone tissue resorption markers in metastatic involvement of the skeleton. Bull Exp Biol Med 125, 286–290 (1998). https://doi.org/10.1007/BF02496884
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02496884