Abstract
Experiments on cats with the use of microelectrode technique and microionophoresis show that semax and ACTH(5–10) modulate spontaneous activity of approximately 60% cortical neurons, which probably accounts for their effect on general integrative function of the cortex. Neurons of the medial vestibular nucleus are highly sensitive to microionophoretic applications of these peptides (59–69% cells). It is assumed that the direct effect of semax and ACTH(5–10) to a great extent determines their efficiency in motion sickness.
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References
I. P. Ashmarin,Pat. Fiziol., No. 3, 3–8 (1988).
V. P. Belyi,Byull. Eksp. Biol. Med.,89, No. 4, 390–392 (1980).
A. N. Gerenko, V. N. Nezavibat'ko, A. V. Volkov, and A. A. Kamenskii,Vestn. Mosk. Univers. (Ser. Biologiya), No. 3, 24–30 (1991).
A. A. Kamenskii, L. V. Antonova, and N. G. Levitskaya,Fiziol. Zh. SSSR, No. 10, 1549–1553 (1980).
V. A. Kislyakov, M. M. Levashov, I. V. Orlov, In:Physiology of Sensory Systems [in Russian], Leningrad (1972), part 2, pp. 57–129
M. A. Ponomareva-Stepnaya, V. N. Nezavibat'ko, L. V. Antonova,et al., Khim. -Farm. Zh., No. 7, 790–795 (1984).
V. A. Pravdivtsev, N. M. Osipov, and V. V. Yasnetsov,Farmakol. Toksikol., No. 2, 224–226 (1981).
V. S. Shashkov, G. S. Aizikov, and V. V. Yasnetsov,Motion Disease (Pathophysiological Mechanisms, Prophylaxis, and Therapy) [in Russian], Moscow (1994).
V. V. Yasnetsov, V. M. Popov, N. M. Kiseleva,et al., Byull. Eksp. Biol. Med.,119, No. 6, 634–636 (1995).
V. V. Yasnetsov, V. A. Pravdivtsev, V. M. Popov,et al. Ibid.,Byull. Eksp. Biol. Med.,119, No. 5, pp. 515–516.
V. V. Yasnetsov and V. S. Shashkov,Neurochemical and Pharmacological Aspects of Motion Disease [in Russian], Moscow (1993).
E. D. Adrian,J. Physiol. (Lond.),101, 389–407 (1993).
I. P. Ashmarin, L. V. Antonova, A. A. Kamensky,et al., Neuropeptides,26, Suppl. 1, 27 (1994).
C. L. Darlington, P. F. Smith, and J. I. Hubbard,Proc. Univ. Otago Med. Sch.,68, 13–14 (1990).
A. Maillis, F. Karayanidis, E. Koutsoukos,et al., Neuropsychobiology, No. 19, 139–145 (1988).
R. S. Snider and W. T. Niemer,A Stereotaxic Atlas of the Cat Brain, Chicago (1961).
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 3, 304–306, March, 1998
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Yasnetsov, V.V., Pravdivtsev, V.A., Krylova, I.N. et al. Effect of semax and ACTH (5–10) on electrical activity of central neurons. Bull Exp Biol Med 125, 268–269 (1998). https://doi.org/10.1007/BF02496878
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DOI: https://doi.org/10.1007/BF02496878