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Initiation of apoptosis in hepatocytes during prolonged arterial hypotension and postresuscitation period

  • Biophysics and Biochemistry
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

An increase in activity of Ca2+, Mg2+-dependent endonucleases on the second hour of hypotension coincided with the presence of DNA fragments in agarose gel. A correlation was established between the duration of hypotension, Ca2+, Mg2+-dependent endonuclease activity, and intensity of nuclear DNA fragmention. Apopotosis of hepatocytes is triggered during ischemia and develops during reperfusion.

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Authors and Affiliations

  1. Laboratory of Experimental Therapy of Terminal States, Institute of General Reanimatology, Russian Academy of Medical Sciences, Moscow

    N. V. Nosova, V. L. Kozhura & I. S. Novoderzhkina

Authors
  1. N. V. Nosova
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  2. V. L. Kozhura
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  3. I. S. Novoderzhkina
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Translated fromByulleten' Eksperimental'noi Biologii i Meditisiny, Vol. 125, No. 3, pp. 285–288, March, 1998

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Nosova, N.V., Kozhura, V.L. & Novoderzhkina, I.S. Initiation of apoptosis in hepatocytes during prolonged arterial hypotension and postresuscitation period. Bull Exp Biol Med 125, 251–254 (1998). https://doi.org/10.1007/BF02496873

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  • DOI: https://doi.org/10.1007/BF02496873

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