Abstract
Adaptation of rats to repetitive hypoxia leads to a decrease in the severity and frequency of arrhythmias induced by epinephrine. Naloxone abolishes antiarrhythmic effect of adaptation. Activation of μ-and δ-opioid receptors is one of the important factors mediating antiarrhythmic effect of adaptation. Intravenous administration of acetorphan, an enkefalinase inhibitor, produces statistically significant antiarrhythmic effect in the control group. Thus, the antiarrhythmic effect of hypoxic adaptation results from activation of μ-and δ-opioid receptors due to increased level of endogenous enkefalins.
Similar content being viewed by others
References
Y. B. Lishmanov, L. N. Maslov, Opiate neuropeptides, stress, and adaptational heart protection, Tomsk (1994).
Y. B. Lishmanov, E. V. Uskina, L. N. Maslov, A. V. Krilatov,Byull. Eksp. Biol.,122, No. 9, 276–278 (1996).
F. Z. Meerson, Adaptation, Stress and Prophylactic, M (1981).
H. D. Allescher, S. Ahmad, E. E. Daniel, et al.,Am. J. Physiol.,255, No. 3, Pt. 1, G352-G360 (1988).
P. R. Burnard, F. Noble, V. Dauge, et al., Pharmacol. Rev.,45, No. 1, 87–146 (1993)
R. Cotton, M. G. Giles, L. Miller, et al.,Eur. J. Pharmacol.,97, 331–332 (1984).
K. P. Mayfield, L. G. D'Alecy,Brain Res.,582, 226–231 (1992).
M. J. Millan, F. C. Colpaert,Neuroscience,42, No. 2, 541–553 (1991).
J. T. Pelton, W. Kazmierski, K. Gulya, et al.,J. Med. Chem.,29, 2370–2375 (1986).
J. E. Shook, J. T. Pelton, W. Kazmierski, et al.,NIDA Res. Monogr.,76, 295–301 (1986).
Author information
Authors and Affiliations
Additional information
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 3, pp. 272–274, March, 1997
Rights and permissions
About this article
Cite this article
Uskina, E.V., Maslov, L.N. & Lishmanov, Y.B. Antiarrhythmic effect of hypoxic preconditioning is mediated by activation of μ- and δ-opioid receptors. Bull Exp Biol Med 125, 239–241 (1998). https://doi.org/10.1007/BF02496869
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02496869