Bulletin of Experimental Biology and Medicine

, Volume 125, Issue 3, pp 239–241 | Cite as

Antiarrhythmic effect of hypoxic preconditioning is mediated by activation of μ- and δ-opioid receptors

  • E. V. Uskina
  • L. N. Maslov
  • Y. B. Lishmanov
General Pathology and Pathological Physiology


Adaptation of rats to repetitive hypoxia leads to a decrease in the severity and frequency of arrhythmias induced by epinephrine. Naloxone abolishes antiarrhythmic effect of adaptation. Activation of μ-and δ-opioid receptors is one of the important factors mediating antiarrhythmic effect of adaptation. Intravenous administration of acetorphan, an enkefalinase inhibitor, produces statistically significant antiarrhythmic effect in the control group. Thus, the antiarrhythmic effect of hypoxic adaptation results from activation of μ-and δ-opioid receptors due to increased level of endogenous enkefalins.

Key Words

opioid receptors opioid peptides hypoxic adaptation arrhythmia 


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  1. 1.
    Y. B. Lishmanov, L. N. Maslov, Opiate neuropeptides, stress, and adaptational heart protection, Tomsk (1994).Google Scholar
  2. 2.
    Y. B. Lishmanov, E. V. Uskina, L. N. Maslov, A. V. Krilatov,Byull. Eksp. Biol.,122, No. 9, 276–278 (1996).Google Scholar
  3. 3.
    F. Z. Meerson, Adaptation, Stress and Prophylactic, M (1981).Google Scholar
  4. 4.
    H. D. Allescher, S. Ahmad, E. E. Daniel, et al.,Am. J. Physiol.,255, No. 3, Pt. 1, G352-G360 (1988).PubMedGoogle Scholar
  5. 5.
    P. R. Burnard, F. Noble, V. Dauge, et al., Pharmacol. Rev.,45, No. 1, 87–146 (1993)Google Scholar
  6. 6.
    R. Cotton, M. G. Giles, L. Miller, et al.,Eur. J. Pharmacol.,97, 331–332 (1984).PubMedCrossRefGoogle Scholar
  7. 7.
    K. P. Mayfield, L. G. D'Alecy,Brain Res.,582, 226–231 (1992).PubMedCrossRefGoogle Scholar
  8. 8.
    M. J. Millan, F. C. Colpaert,Neuroscience,42, No. 2, 541–553 (1991).PubMedCrossRefGoogle Scholar
  9. 9.
    J. T. Pelton, W. Kazmierski, K. Gulya, et al.,J. Med. Chem.,29, 2370–2375 (1986).PubMedCrossRefGoogle Scholar
  10. 10.
    J. E. Shook, J. T. Pelton, W. Kazmierski, et al.,NIDA Res. Monogr.,76, 295–301 (1986).Google Scholar

Copyright information

© Plenum Publishing Corporation 1998

Authors and Affiliations

  • E. V. Uskina
    • 1
  • L. N. Maslov
    • 1
  • Y. B. Lishmanov
    • 1
  1. 1.Department of Experimental Cardiology Institute of CardiologySiberian Division of the Russian Academy of Medical ScienceTomsk

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