Biological properties of human mutant tumor necrosis factor-α
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Antitumor activities of tumor necrosis factor-α and its mutant analog R31Q are studied in HEp-2 and U-937 cell cultures. Cytotoxic activity of R31Q virtually does not differ from that of the initial form of tumor necrosis factor-α and its cytostatic effect was even slightly higher. The nonspecific toxicity of R31Q toward human diploid fibroblasts L-68 is lower. Comparative study of the drug pharmacokineticsin vivo showed a better preservation and higher concentration in the blood of the mutant analog of tumor necrosis factor-α.
Key Wordsmutant tumor necrosis factor antitumor activity pharmacokinetics
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