Biological properties of human mutant tumor necrosis factor-α
- 21 Downloads
Antitumor activities of tumor necrosis factor-α and its mutant analog R31Q are studied in HEp-2 and U-937 cell cultures. Cytotoxic activity of R31Q virtually does not differ from that of the initial form of tumor necrosis factor-α and its cytostatic effect was even slightly higher. The nonspecific toxicity of R31Q toward human diploid fibroblasts L-68 is lower. Comparative study of the drug pharmacokineticsin vivo showed a better preservation and higher concentration in the blood of the mutant analog of tumor necrosis factor-α.
Key Wordsmutant tumor necrosis factor antitumor activity pharmacokinetics
Unable to display preview. Download preview PDF.
- 1.A. E. Korepanova, A. M. Eroshkin, V. A. Ivanisenko,et al., Molekul. Biologiya,28, No. 1, 143–149 (1994).Google Scholar
- 2.L. R. Lebedev, Yu. P. Zernov, I. S. Andreeva, and N. M. Pustoshilova,Biotechnologiya, No. 12, 19–24 (1995).Google Scholar
- 3.L. N. Shingarova, L. N. Sagaidak, R. P. Turetskaya,et al., Bioorgan. Khimiya,22, No. 4, 243–251 (1996).Google Scholar
- 9.K. J. Tracey, in:Cytokine Handbook, ed. A. Tompson (1994), pp. 289–304.Google Scholar