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Effect of haloperidol and amphetamine on conditioning and functional disturbances in avoidance reaction

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

We compared the effects of haloperidol and amphetamine on the conditioning of the avoidance reaction in rats and its revesible disturbances by delivering electrical stimuli conflicting with the established relation between stimulation, responses, and their consequences. Amphetamine accelerates conditioning of avoidance reaction and diminishes the impact of functional disturbances. Haloperidol in a dose of 0.1 mg/kg completely inhibits avoidance but not intersignal reactions; in animals injected with 0.01 mg/kg haloperidol, avaidance reactions can be conditioned but less effective than in control animals. Functional disturbances inhibit avoidance and increase the number of intersignal reactions. These findings suggest that haloperidol in low doses activates generalized motor activity and does not improve adaptive reactions timed with conditioning stimulus and ensuring escape from electrical footshock.

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Authors and Affiliations

  1. Laboratory of Evolution of Memory Mechanisms, Biological Faculty of M. V. Lomonosov Moscow State University, Moscow

    A. N. Inozemtsev, S. B. Bokieva, A. B. Spinei, T. A. Voronina & N. A. Tushmalova

  2. Laboratory of Psychopharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow

    A. N. Inozemtsev, S. B. Bokieva, A. B. Spinei, T. A. Voronina & N. A. Tushmalova

Authors
  1. A. N. Inozemtsev
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  2. S. B. Bokieva
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  3. A. B. Spinei
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  4. T. A. Voronina
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  5. N. A. Tushmalova
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 1, pp. 56–58, January, 1998

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Inozemtsev, A.N., Bokieva, S.B., Spinei, A.B. et al. Effect of haloperidol and amphetamine on conditioning and functional disturbances in avoidance reaction. Bull Exp Biol Med 125, 47–49 (1998). https://doi.org/10.1007/BF02496799

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  • DOI: https://doi.org/10.1007/BF02496799

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