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Hypotensive effect and tissue distribution of the dinitrosyl iron complexes, a nitric oxide donor

  • General Pathology and Pathological Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Hypotensive effect of the dinitrosyl iron complexes, an NO donor, is compared with distribution of these complexes in organs and tissues after their intravenous administration to wakeful animals. Hypotensive effect of iron complexes depended on dose and postinjection time. There was a strong correlation between hypotensive effect and the content of dinitrosyl iron complex in the studied organs. Effective dose of dinitrosyl iron complexes that did not provoke adverse effects was about 200 mg/kg. This preparation is a prospective source of NO to treat and prevent pathological states related to NO deficiency.

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Authors and Affiliations

  1. Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow

    E. B. Manukhina, I. Yu. Malyshev, E. B. Malenyuk, T. A. Zenina & D. A. Podkidyshev

  2. Institute of Chemical Physics, Russian Academy of Sciences, Moscow

    V. D. Mikoyan, L. N. Kubrina & A. F. Vanin

Authors
  1. E. B. Manukhina
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  2. I. Yu. Malyshev
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  3. E. B. Malenyuk
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  4. T. A. Zenina
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  5. D. A. Podkidyshev
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  6. V. D. Mikoyan
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  7. L. N. Kubrina
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  8. A. F. Vanin
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Additional information

Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 1, pp. 30–33, January, 1998

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Manukhina, E.B., Malyshev, I.Y., Malenyuk, E.B. et al. Hypotensive effect and tissue distribution of the dinitrosyl iron complexes, a nitric oxide donor. Bull Exp Biol Med 125, 23–25 (1998). https://doi.org/10.1007/BF02496792

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  • DOI: https://doi.org/10.1007/BF02496792

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