Abstract
The content of nitric oxide in convulsions of different genesis is assessed by measuring the formation of paramagnetic mononitrosyl iron complexes with diethylthiocarbamate by electron paramagnetic resonance. A 3- to 4-fold increase in the content of these complexes is found in the brain of rats with thiosemicarbazide- or N-methyl-DL-aspartate-induced seizures in comparison with control animals. A similar increase in the brain NO content was observed in maximum electrical stimulation of metrazol-induced convulsions. These changes were accompanied by elevation of secondary lipid peroxidation products.
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References
V. G. Bashkatova, G. Yu. Vitskova, V. B. Narkevich,et al., Neurockhimiya,13, No. 2, 110–115 (1996).
V. G. Bashkatova, V. D. Mikoyan, E. S. Kosacheva,et al., Dokl. Rus. Akad. Nauk,348, No. 1, 119–121 (1996).
A. F. Vanin, P. I. Mordvintsev, and A. L. Klechev,Stud. Biophys.,102, 125–137 (1984).
K. S. Raevskii and V. P. Georgiev,Transmitter Amino Acids: Neuropharmacology and Neurochemistry [in Russian], Moscow (1986).
V. Bashkatova, E. S. Kosacheva, V. D. Mikoyan,et al.,Pharmacol. Res.,31, Suppl. 57 (1995).
C. Chiueh, P. Rauhala, and I. Sziraki,Soc. Neurosci Abstr.,22, No. 1, 720 (1996).
G. De Sarro, E. D. Di Paola, A. De Sarro, and M. J. Vidal,Eur. J. Pharmacol.,230, 151–158 (1993).
R. Maggio, F. Fumagalli, E. Donati,et al., Brain Res.,679, 184–187 (1995).
O. Manzoni, L. Prezeau, P. Marin,et al., Neuron,8, 653–662 (1992).
V. Mollace, G. Bagetta, and G. Nistico,Neuroreport,2, 269–272 (1991).
S. Moncada and A. Higgs,N. Engl. J. Med. 329, No. 27, 2003–2011 (1993).
A. Mulsch, R. Busse, P. Mordvintsev,et al., Neuroreport,5, 2325–2328 (1994).
H. Ohkawa, N. Ohishi, and K. Yagi,Anal Biochem.,95, 351–358 (1979).
E. Przegalinski, L. Baran, and J. Siwanowicz,Neurosci. Lett.,170, 74–76 (1994).
C. Rundfeldt, R. Koch, A. Richter,et al., Eur. J. Pharmacol.,274, 73–81 (1995).
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Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 125, No. 1, pp. 26–29, January, 1998
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Bashkatova, V.G., Vitskova, G.Y., Narkevich, V.B. et al. Possible involvement of nitric oxide in the pathogenesis of experimental convulsions of various genesis. Bull Exp Biol Med 125, 20–22 (1998). https://doi.org/10.1007/BF02496791
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DOI: https://doi.org/10.1007/BF02496791