Synthesis of acetonylmalonaldehyde and its interaction with aminoazoles
Acetonylmalonaldehyde (1) was obtained for the first time by hydrolysis of 2,5-dimethoxy-5-methyltetrahydrofuran-3-carbaldehyde. The interaction of1 with 3-amino-5-methylpyrazole, 3-amino-1,2,4-triazole, 2-aminobenzimidazole, and 5-aminotetrazole results in the formation of functionally substituted azolopyrimidines.
Key wordstetrahydrofurans, hydrolysis acetonylmalonaldehyde, aminoazoles, reaction
- 1.A. V. Khandin, M. M. Vartanyan, and L. Yu. Brezhnev,Izv. Akad. Nauk SSSR, Ser. Khim., 1989, 2389 [Bull. Acad. Sci. USSR, Div. Chem. Sci., 1989,38, 2200 (Engl. Transl.)].Google Scholar
- 2.M. M. Vartanyan, O. L. Eliseev, T. Yu. Solov'eva, B. I. Ugrak, and Kh. R. Skov,Izv. Akad. Nauk, Ser. Khim., 1994, 1997 [Russ. Chem. Bull., 1994,43, 1884 (Engl. Transl.)].Google Scholar
- 3.N. N. Shapet'ko, A. V. Kessenikh, A. P. Skoldinov, and T. V. Protopopova,Teor. Eksp. Khim., 1966,2, 757 [Theor. Exp. Chem., 1966,2 (Engl. Transl.)].Google Scholar